Diazolidinyl urea
Based on 1 Customer Validation
Diazolidinyl urea is a broad-spectrum preservative commonly used in cosmetics. Diazolidinyl urea exerts antibacterial effects by decomposing and releasing formaldehyde. Diazolidinyl urea is effective against most contaminating microorganisms, especially Pseudomonas.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 78491-02-8
- Formula: C8H14N4O7
- Molecular Weight:278.22
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Diazolidinyl urea (0.3 %) exhibits antimicrobial activity against bacteria such as P. aeruginosa, S. marcescens, and S. epidermidis, with kill times ranging from 6 to 24 h and D-values (90% kill time) of 42-86 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 78491-02-8
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Appearance Solid
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Molecular Weight 278.22
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Formula C8H14N4O7
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Color White to off-white
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SMILES
O=C(NCO)N(C(C(N1CO)=O)N(CO)C1=O)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL (898.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 166.67 mg/mL (599.06 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4.17 mg/mL (14.99 mM); Clear solution
This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 4.17 mg/mL (14.99 mM); Clear solution
This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 110 mg/mL (395.37 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Llabres CM, et al. Antimicrobial activities of N-chloramines and diazolidinyl urea. Appl Environ Microbiol. 1985 Feb;49(2):370-3. [Content Brief]
[2]. Kantor GR, et al. Acute allergic contact dermatitis from diazolidinyl urea (Germall II) in a hair gel. J Am Acad Dermatol. 1985;13(1):116-119. [Content Brief]
[3]. Doi T, et al. The different decomposition properties of diazolidinyl urea in cosmetics and patch test materials. Contact Dermatitis. 2011;65(2):81-91. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.5943 mL | 17.9714 mL | 35.9428 mL | 89.8569 mL |
| 5 mM | 0.7189 mL | 3.5943 mL | 7.1886 mL | 17.9714 mL | |
| 10 mM | 0.3594 mL | 1.7971 mL | 3.5943 mL | 8.9857 mL | |
| 15 mM | 0.2396 mL | 1.1981 mL | 2.3962 mL | 5.9905 mL | |
| 20 mM | 0.1797 mL | 0.8986 mL | 1.7971 mL | 4.4928 mL | |
| 25 mM | 0.1438 mL | 0.7189 mL | 1.4377 mL | 3.5943 mL | |
| 30 mM | 0.1198 mL | 0.5990 mL | 1.1981 mL | 2.9952 mL | |
| 40 mM | 0.0899 mL | 0.4493 mL | 0.8986 mL | 2.2464 mL | |
| 50 mM | 0.0719 mL | 0.3594 mL | 0.7189 mL | 1.7971 mL | |
| 60 mM | 0.0599 mL | 0.2995 mL | 0.5990 mL | 1.4976 mL | |
| 80 mM | 0.0449 mL | 0.2246 mL | 0.4493 mL | 1.1232 mL | |
| 100 mM | 0.0359 mL | 0.1797 mL | 0.3594 mL | 0.8986 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Diazolidinyl urea Related Classifications
HY-W009350 Related Classifications
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