Vipivotide tetraxetan Ligand-Linker Conjugate (Synonyms: PSMA-617 Ligand-Linker Conjugate)

Name: Vipivotide tetraxetan Ligand-Linker Conjugate
Brand: MedChemExpress
SKU: HY-43869
Rating: 4.5 (1 reviews)

Cat. No.: HY-43869 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

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Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA).

For research use only. We do not sell to patients.

Vipivotide tetraxetan Ligand-Linker Conjugate Chemical Structure

CAS No. : 1703768-74-4

Size	Price	Stock	Quantity
5 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2300	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

Non-cleavable Linker

In Vitro

Vipivotide tetraxetan Ligand-Linker Conjugate

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

655.74

Formula

C₃₃H₄₅N₅O₉

CAS No.

1703768-74-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H](CCCCNC([C@H](CC1=CC=C2C=CC=CC2=C1)NC([C@H]3CC[C@H](CN)CC3)=O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (190.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5250 mL	7.6250 mL	15.2499 mL
5 mM	0.3050 mL	1.5250 mL	3.0500 mL
10 mM	0.1525 mL	0.7625 mL	1.5250 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (245 KB) HNMR (333 KB) LCMS (250 KB)

Handling Instructions (2659 KB)

References

[1]. Benešová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5250 mL	7.6250 mL	15.2499 mL	38.1249 mL
	5 mM	0.3050 mL	1.5250 mL	3.0500 mL	7.6250 mL
	10 mM	0.1525 mL	0.7625 mL	1.5250 mL	3.8125 mL
	15 mM	0.1017 mL	0.5083 mL	1.0167 mL	2.5417 mL
	20 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.9062 mL
	25 mM	0.0610 mL	0.3050 mL	0.6100 mL	1.5250 mL
	30 mM	0.0508 mL	0.2542 mL	0.5083 mL	1.2708 mL
	40 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9531 mL
	50 mM	0.0305 mL	0.1525 mL	0.3050 mL	0.7625 mL
	60 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6354 mL
	80 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.4766 mL
	100 mM	0.0152 mL	0.0762 mL	0.1525 mL	0.3812 mL

Vipivotide tetraxetan Ligand-Linker Conjugate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vipivotide tetraxetan Ligand-Linker Conjugate1703768-74-4PSMA-617 Ligand-Linker ConjugateADC LinkerAntibody-drug conjugates linkernonclaevableprostateradioactiveligandcancerInhibitorinhibitorinhibit

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Vipivotide tetraxetan Ligand-Linker Conjugate (Synonyms: PSMA-617 Ligand-Linker Conjugate)

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Vipivotide tetraxetan Ligand-Linker Conjugate Related Antibodies

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Complete Stock Solution Preparation Table

Vipivotide tetraxetan Ligand-Linker Conjugate Related Classifications

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