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Cat. No.: HY-145872

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HBV-IN-20

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).

For research use only. We do not sell to patients.

CAS No.: 2750254-34-1
Formula: C₁₆H₁₈ClFN₂O₂
Molecular Weight:324.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

HBV-IN-20 Chemical Structure

CAS No.: 2750254-34-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC₅₀ of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators)^[1].

IC₅₀ & Target

EC₅₀: 0.46 µM (HBV)^[1]

In Vitro

HBV-IN-20 (compound 61) (5 µM; 6 days) is a typical type II CpAM (core protein assembly modula tors)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepDES19 cells
Concentration:

5 µM
Incubation Time:
Result:

Was a typical type II CpAM (core protein assembly modula tors).

In Vivo

HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability^[1].
Pharmacokinetic Parameters of HBV-IN-20 in mouse^[1].

Compd	Admin.	Cl-obs (mL/min/kg)	T_1/2 (hr)	AUC_last (h*ng/mL)	V_ss-obs (L/kg)	C_max (ng/mL)	F (%)
61	i.v.	25.5	0.6	1952	0.8
	p.o.		0.7	4516		2727	69

Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse^[1]
Dosage:
Administration:

3 mg/kg for i.v.; 10 mg/kg for p.o.
Result:

Showed 69% of oral bioavailability.

Chemical Information

CAS No. 2750254-34-1
Molecular Weight 324.78
Formula C₁₆H₁₈ClFN₂O₂
SMILES

ClC(C=C1NC(N2[C@@]3([H])[C@@](CCCC3)([H])C(CC2)=O)=O)=C(C=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hwang N, et al. 4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators. Bioorg Med Chem Lett. 2022; 58:128518. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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