1. Anti-infection
  2. HBV
  3. HBV-IN-20

HBV-IN-20 

Cat. No.: HY-145872
Handling Instructions

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).

For research use only. We do not sell to patients.

HBV-IN-20 Chemical Structure

HBV-IN-20 Chemical Structure

CAS No. : 2750254-34-1

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Description

HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators)[1].

IC50 & Target

EC50: 0.46 µM (HBV)[1]

In Vitro

HBV-IN-20 (compound 61) (5 µM; 6 days) is a typical type II CpAM (core protein assembly modula tors)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HepDES19 cells
Concentration: 5 µM
Incubation Time:
Result: Was a typical type II CpAM (core protein assembly modula tors).
In Vivo

HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability[1].
Pharmacokinetic Parameters of HBV-IN-20 in mouse[1].

Compd Admin. Cl-obs (mL/min/kg) T1/2 (hr) AUClast (h*ng/mL) Vss-obs (L/kg) Cmax (ng/mL) F (%)
61 i.v. 25.5 0.6 1952 0.8
p.o. 0.7 4516 2727 69
Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage:
Administration: 3 mg/kg for i.v.; 10 mg/kg for p.o.
Result: Showed 69% of oral bioavailability.
Molecular Weight

324.78

Formula

C16H18ClFN2O2

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
HBV-IN-20
Cat. No.:
HY-145872
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