2. Membrane Transporter/Ion Channel Neuronal Signaling TGF-beta/Smad Epigenetics Anti-infection Apoptosis
  3. Calcium Channel PKC Bacterial Apoptosis Antibiotic
  4. Ionomycin

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

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CAS No. : 56092-81-0

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1 mg (14.1 mM * 100 μL in Ethanol) 해외재고보유
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5 mg (14.1 mM * 500 μL in Ethanol) 해외재고보유
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10 mg (14.1 mM * 1 mL in Ethanol) 해외재고보유
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25 mg (14.1 mM * 2.5 mL in Ethanol) 해외재고보유
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50 mg (14.1 mM * 5 mL in Ethanol) 해외재고보유

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고객리뷰

Based on 120 publication(s) in Google Scholar

Other Forms of Ionomycin:

Ionomycin Related Antibodies

Top Publications Citing Use of Products

120 Publications Citing Use of MCE Ionomycin

Cell Imaging/Staining
Flow Cytometry
RT-PCR
ELISA
IF

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102.  [Abstract]

    CcPKCα modulation by Ionomycin (1 μM in 0.1% DMSO)

    Ionomycin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Mar 15;83(6):906-921.  [Abstract]

    The expression of IFNγ or TNFα in CD8+ T cells isolated from B16 tumors was analyzed after re-stimulation by PMA, Ionomycin (500 ng/mL), and BFA for 4 hours in vitro.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2203869.  [Abstract]

    Ionomycin (10 μM) served as the positive drug quenching mitochondrial calcein fluorescence.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Jul 7;82(13):2401-2414.e9.  [Abstract]

    Representative images of undivided OT-I CD8+ T cells activated on slides coated with anti-CD3, anti-CD28, and ICAM1 or with PMA plus Ionomycin (1 μM) for 2 h.

    Ionomycin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 Mar 1:303:116031.  [Abstract]

    Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM Ionomycin, respectively.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301.  [Abstract]

    Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to RT-qPCR.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301.  [Abstract]

    Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to ELISA.

    View All Calcium Channel Isoform Specific Products:

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

    View All PKC Isoform Specific Products:

    View All Isoforms
    PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

    View All Antibiotic Isoform Specific Products:

    View All Isoforms
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    제품 설명

    Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

    IC50 & Target

    Calcium ionophore[1]
    In Vitro

    Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
    Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
    Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].
    Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ionomycin Related Antibodies
    분자량

    709.01

    화학식

    C41H72O9
    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
    Structure Classification
    Initial Source

    Streptomyces conglobatus
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    Solution, -20°C, 2 years
    순도&문서

    Purity: 99.27%

    SDS (396 KB)

    COA (242 KB)

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    Ionomycin Related Classifications

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    Keywords:

    Ionomycin56092-81-0SQ23377SQ 23377SQ-23377Calcium ChannelPKCBacterialApoptosisAntibioticCa2+ channelsCa channelsProtein kinase CcleavageexosomecalciumionophoreantibioticInhibitorinhibitorinhibit

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    Cat. No.:
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