2. Membrane Transporter/Ion Channel Neuronal Signaling TGF-beta/Smad Epigenetics Anti-infection Apoptosis
  3. Calcium Channel PKC Bacterial Apoptosis Antibiotic
  4. Ionomycin

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

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No. CAS : 56092-81-0

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1 mg (14.1 mM * 100 μL in Ethanol) En stock
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5 mg (14.1 mM * 500 μL in Ethanol) En stock
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10 mg (14.1 mM * 1 mL in Ethanol) En stock
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25 mg (14.1 mM * 2.5 mL in Ethanol) En stock
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50 mg (14.1 mM * 5 mL in Ethanol) En stock

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Revisión del cliente

Based on 120 publication(s) in Google Scholar

Other Forms of Ionomycin:

Ionomycin Related Antibodies

Top Publications Citing Use of Products

120 Publications Citing Use of MCE Ionomycin

Cell Imaging/Staining
Flow Cytometry
RT-PCR
ELISA
IF

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e10102.  [Abstract]

    CcPKCα modulation by Ionomycin (1 μM in 0.1% DMSO)

    Ionomycin purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Mar 15;83(6):906-921.  [Abstract]

    The expression of IFNγ or TNFα in CD8+ T cells isolated from B16 tumors was analyzed after re-stimulation by PMA, Ionomycin (500 ng/mL), and BFA for 4 hours in vitro.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2203869.  [Abstract]

    Ionomycin (10 μM) served as the positive drug quenching mitochondrial calcein fluorescence.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Jul 7;82(13):2401-2414.e9.  [Abstract]

    Representative images of undivided OT-I CD8+ T cells activated on slides coated with anti-CD3, anti-CD28, and ICAM1 or with PMA plus Ionomycin (1 μM) for 2 h.

    Ionomycin purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2023 Mar 1:303:116031.  [Abstract]

    Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM Ionomycin, respectively.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301.  [Abstract]

    Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to RT-qPCR.

    Ionomycin purchased from MedChemExpress. Usage Cited in: Protein Cell. 2022 Apr;13(4):281-301.  [Abstract]

    Jurkat T cells were treated with different concentration of NFV or CsA for 2 h, following stimulation with PMA (100 nmol/L) and Ionomycin (10 μmol/L) for 24 h. After treatment, cells and culture supernatant were collected and subjected to ELISA.

    Ver todos los productos específicos de isoformas Calcium Channel:

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

    Ver todos los productos específicos de isoformas PKC:

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    PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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    Descripciòn

    Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

    IC50 & Target

    Calcium ionophore[1]
    In Vitro

    Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
    Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
    Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].
    Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ionomycin Related Antibodies
    Peso molecular

    709.01

    Fòrmula

    C41H72O9
    No. CAS
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
    Structure Classification
    Initial Source

    Streptomyces conglobatus
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Solution, -20°C, 2 years
    Pureza y Documentación

    Purity: 99.27%

    SDS (396 KB)

    COA (242 KB)

    Instrucciones de manejo (2659 KB)
    Referencias
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    Ionomycin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ionomycin56092-81-0SQ23377SQ 23377SQ-23377Calcium ChannelPKCBacterialApoptosisAntibioticCa2+ channelsCa channelsProtein kinase CcleavageexosomecalciumionophoreantibioticInhibitorinhibitorinhibit

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    Nombre del producto:
    Ionomycin
    Cat. No.:
    HY-13434
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