2. 疾患モデリングル製品 Immunology/Inflammation Anti-infection NF-κB Autophagy Apoptosis MAPK/ERK Pathway
  3. Immunology and Inflammatory Disease Models Digestive System Disease Models COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK
  4. Gastrointestinal Inflammation and Ulcer Models Gastrointestinal Disease Models
  5. Gastric Ulcer Models
  6. Aspirin lithium

Aspirin lithium  (Synonyms: Acetylsalicylic acid lithium; ASA lithium)

製品番号: HY-14654A
取扱説明書 Technical Support

Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.

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CAS 番号 : 552-98-7

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Aspirin lithium 関連抗体

Top Publications Citing Use of Products

顧客検証

In Vivo Efficacy Study
Histological Imaging/Staining
IHC
WB

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.  [Abstract]

    C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). PLS-DA of 16S sequencing (n=6/group) (Asp 0d vs Asp 14d).

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.  [Abstract]

    C57BL/6J mice were treated with aspirin [2 mg/mL (11.1 mM) in drinking water] for 2 weeks and feces collected for 16S sequencing (n=6/group). The three indexes of α-diversity of mice fecal microbiota (Asp 0d vs Asp 14d).

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.  [Abstract]

    C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Representative images of H&E staining of intestine and injury scores for each group are shown. Random 10 positions of distal jejunum were picked and the average scores calculated for all mice (n=10 replicates/group). Scale bar: 200 μm.

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.  [Abstract]

    C57BL/6J mice were subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin). Ki67 staining of distal jejunum of mice. The quantitative comparison of Ki67 staining of intestinal crypts (red dotted lines, n = 5/group) were shown.

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.  [Abstract]

    Transmission Electron Microscopy (TEM) of intestinal tissues from mice subjected to oral aspirin treatment for 2 weeks by adding aspirin into the drinking water at a concentration of 2 mg/mL (11.1mM), with or without antibiotics (neomycin).

    Aspirin lithium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

    COX アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    COX COX-1 COX-2 COX-3

    NF-κB アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    Caspase アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

    p38 MAPK アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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    製品説明

    Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].

    IC50 & Target

    COX-1

     

    COX-2

     

    体外実験

    Aspirin lithium inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively[2].
    Aspirin lithium acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation[3].
    Aspirin lithium inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer[3].
    Aspirin lithium inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells[4].
    Aspirin lithium induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Aspirin lithium 関連抗体
    体内実験

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Aspirin lithium (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats[7].
    Aspirin can be used to induce gastrointestinal ulcer models[8].

    Induction of gastric Ulcer Model[8]
    Background
    Aspirin inhibits the synthesis of endogenous prostaglandins (PGs) in animals. Aspirin can also lyse mucosal epithelial cells phospholipids, resulting in increased mucosal permeability.
    Specific Modeling Methods
    Mice: Albino • male • 6-week-old
    Administration: 500 mg/kg • oral • single dose
    Modeling Indicators
    Behavior Observation: Caused erosion of the surface epithelial cell.
    Resulted in a decrease in the mucosal thickness.
    Induced ulcer without COX-1 reaction.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 mL/kg of a 20% aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)[7]
    Dosage: 5, 25, 50, 100 and 150 mg/kg
    Administration: PO, once
    Result: Produced a statistically significant decrease of 0.23°C at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 °C was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.
    Animal Model: Albino male mice [8]
    Dosage: 500 mg/kg, single dose
    Administration: oral
    Result: Caused erosion of the surface epithelial cells.
    Resulted in a decrease in the mucosal thickness.
    Induced ulcer without COX-1 reaction.
    分子量

    186.09

    分子式

    C9H7LiO4
    CAS 番号
    SMILES

    O=C(O[Li])C1=CC=CC=C1OC(C)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    Aspirin lithium Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aspirin552-98-7Acetylsalicylic acidASACOXVirus ProteaseNF-κBAutophagyApoptosisMitophagyCaspasep38 MAPKCyclooxygenaseNuclear factor-κBNuclear factor-kappaBMitochondrial AutophagyAntipyretic effectfeverinflammationcerebrovascular thrombosiscoronary arteryplateletprostaglandin synthetasecancerInhibitorinhibitorinhibit

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