2. Anti-infection Cytoskeleton Cell Cycle/DNA Damage Stem Cell/Wnt JAK/STAT Signaling Apoptosis Autophagy
  3. Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy
  4. Flubendazole

Flubendazole  (Synonyms: フルベンダゾール)

製品番号: HY-B0294 純度: 99.05%
COA 取扱説明書 Technical Support

Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites.

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Flubendazole

Flubendazole 構造式

CAS 番号 : 31430-15-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 79 在庫あり
Solution
10 mM * 1 mL in DMSO USD 79 在庫あり
Solid
100 mg $72 在庫あり
500 mg $108 在庫あり
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Based on 8 publication(s) in Google Scholar

Other Forms of Flubendazole:

Flubendazole 関連抗体

Top Publications Citing Use of Products

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すべてのアイソフォームを表示
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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STAT3 STAT5 STAT6 STAT1

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製品説明

Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites[1][2].

IC50 & Target[1][2]

STAT3

 

Cellular Effect
Cell Line Type Value Description References
BT-549 IC50
0.125 μM
Compound: 28; 65
Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human BT-549 cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
Hs-578T IC50
0.125 μM
Compound: 28; 65
Anticancer activity against human Hs-578T cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human Hs-578T cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
MDA-MB-231 IC50
0.25 μM
Compound: 28; 65
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTS assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTS assay
[PMID: 33650861]
MDA-MB-231 IC50
0.5 μM
Compound: 28; 65
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 33650861]
MDA-MB-231 IC50
0.75 μM
Compound: 14
Antiproliferative activity against human MDA-MB-231 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37595546]
PC-3M EC50
1.43 μM
Compound: Flubendazole
Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay
Cytotoxicity against human PC3M cells assessed as reduction in cell viability after 48 hrs by cyquant reagent based fluorescence spectrometric assay
[PMID: 29288939]
体外実験

Flubendazole (0-400 μM; 48 h) inhibits human colorectal cancer (CRC) cells proliferation[1].
Flubendazole (0.3-1.2 μM; 48 h) induces apoptosis in CRC cells[1].
Flubendazole (0.3-1.2 μM; 24 h) induces autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II in CRC cells[1].
Flubendazole (0.3-1.2 μM; 24 h) strongly reduces the expression of P-STAT3 in a dose and time-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flubendazole 関連抗体

Cell Viability Assay[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0-400 μM
Incubation Time: 48 h
Result: Effectively reduces the viability of CRC cells (HCT116, RKO and SW480) in a concentration-dependent manner, with an IC50 of 2-5 μM.

Apoptosis Analysis[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 48 h
Result: Increased the proportion of apoptotic cells in a dose-dependent manner.
Dose-dependently effectively increases caspase-3 activity.

Cell Autophagy Assay[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 24 h
Result: Induced autophagy initiation by inactivating mTOR and P62, and upregulating LC3-I/II, which are classical marker of autophagy.

Western Blot Analysis[1]

Cell Line: CRC cells (HCT116, RKO and SW480)
Concentration: 0.3, 0.6, 1.2 μM
Incubation Time: 24 h
Result: Strongly reduced the expression of phosphorylated STAT3 (P-STAT3) in a dose and time-dependent manner.
No obvious change in total STAT3 expression.
Decreased expression of MCL1 and survivin in a dose-dependent manner.
体内実験

Flubendazole (10, 30 mg/kg; i.p; every other day; 14 days) inhibits growth of CRC tumor xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c athymic nude mice (6-8 weeks) with HCT116 cells[1]
Dosage: 10  or 30 mg/kg
Administration: Intraperitoneal injection; every other day; 14 days
Result: Markedly reduced the tumor volume.
Significantly reduces the protein level of P-STAT3, promotes autophagy and induces apoptosis in vivo.
分子量

313.28

分子式

C16H12FN3O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC)NC1=NC2=CC=C(C(C3=CC=C(F)C=C3)=O)C=C2N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 4.17 mg/mL (13.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1920 mL 15.9602 mL 31.9203 mL
5 mM 0.6384 mL 3.1920 mL 6.3841 mL
10 mM 0.3192 mL 1.5960 mL 3.1920 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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濃度 （終了）

C2

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体積 （終了）

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体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 5 mg/mL (15.96 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.05%

COA (246 KB) LCMS (99 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1920 mL 15.9602 mL 31.9203 mL 79.8008 mL
5 mM 0.6384 mL 3.1920 mL 6.3841 mL 15.9602 mL
10 mM 0.3192 mL 1.5960 mL 3.1920 mL 7.9801 mL
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Flubendazole Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flubendazole31430-15-6ParasiteMicrotubule/TubulinSTATMDM-2/p53ApoptosisAutophagyAnthelminticmicrotubuletubulin polymerizationCRCCyclin B1p-cdc2wormintestinal parasitescolorectal cancerInhibitorinhibitorinhibit

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