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Results for "

human-factor-xi

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (2) Autophagy (2) Bacterial (4) Bcl-2 Family (2) Caspase (2) CDK (2) Complement System (2) Dipeptidyl Peptidase (1) Drug Derivative (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) Factor Xa (6) Factor XI (6) GSK-3 (1) Kallikrein (2) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (3) MMP (3) NF-κB (2) PARP (1) Phospholipase (2) PKC (2) PROTACs (2) Proteasome (1) Reference Standards (2) Ser/Thr Protease (2) Sodium Channel (1) TGF-beta/Smad (1) Thrombin (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (16) Endocrinology (1) Infection (3) Inflammation/Immunology (12) Metabolic Disease (6) Neurological Disease (6)
Oligonucleotides:	siRNA drugs (2) Antisense Oligonucleotides (2) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117930

Danicopan 4 Publications Verification ACH-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-N0758

Barlerin 8-O-Acetyl shanzhiside methyl ester	Caspase NF-κB	Inflammation/Immunology
Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB.

HY-117610A

Bisindolylmaleimide XI hydrochloride 3 Publications Verification Ro 32-0432; Ro 31-8830 hydrochloride	PKC	Inflammation/Immunology
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC₅₀s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively .

HY-108638

NSC 146109 hydrochloride 2 Publications Verification xi-011 hydrochloride	MDM-2/p53 Apoptosis PARP	Cancer
NSC 146109 hydrochloride (XI-011 hydrochloride) is a p53 activator and MDMX inhibitor. NSC 146109 hydrochloride inhibits MDMX gene transcription, downregulates MDMX mRNA and protein levels, stabilizes p53 and activates the transcriptional activity of p53. NSC 146109 hydrochloride induces cancer cell apoptosis (apoptosis) and inhibits the growth of transformed cells. NSC 146109 hydrochloride inhibits the growth of xenograft tumors. NSC 146109 hydrochloride can be used in research related to breast cancer and cervical cancer .

HY-119124

Edoxaban M4 D21-2393	Factor Xa	Cardiovascular Disease Inflammation/Immunology
Edoxaban M4 (D21-2393) is an orally active and selective Factor Xa inhibitor with a human Factor Xa IC₅₀ of 1.8 nM. Edoxaban M4 exhibits anticoagulant activity via Factor Xa inhibition. Edoxaban M4 can be used for the research of non-valvular atrial fibrillation, venous thromboembolisms, pulmonary embolism .

HY-111518

JH-XI-10-02 2 Publications Verification	PROTACs CDK	Cancer
JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC₅₀ of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19 .

HY-14714

NSC-207895 2 Publications Verification xi-006	MDM-2/p53	Cancer
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator .

HY-156613

Frunexian EP-7041	Factor XI	Infection
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research .

HY-118969

BMS-262084	Factor Xa Ser/Thr Protease	Cardiovascular Disease
BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC₅₀ of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC₅₀=5 nM). BMS-262084 exhibits antithrombotic effects .

HY-P5542

Vicatertide SB-01; Peniel 2000	Factor Xa TGF-beta/Smad	Inflammation/Immunology
Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a K_a of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases .

HY-N10793

RA-XI	Others	Cancer
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-112388

GSK-3b Inhibitor XI 1 Publications Verification	GSK-3	Neurological Disease Metabolic Disease
GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a K_i value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease .

HY-175735

Factor XI-IN-2	Factor XI	Cardiovascular Disease
Factor XI-IN-2 is a Factor XI activation inhibitor with an IC₅₀ of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-143477

Factor XI-IN-1	Factor XI	Cardiovascular Disease
Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC₅₀ of 25.14 nM .

HY-NP126

Highly purified Type XI collagen, from porcine articular cartilage Porcine Type xi collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-151196

FXIa-IN-10	Factor Xa	Cardiovascular Disease
FXIa-IN-10 (Compound 3f) is a potent *activated factor* XI (FXIa) inhibitor with an K_i** of 0.17 nM. FXIa-IN-10 has good oral bioavailability .

HY-N6803

Polygalaxanthone XI	Others	Neurological Disease
Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, and tranquilizing agent .

HY-125001

JH-VIII-49	CDK Ligands for Target Protein for PROTAC	Cancer
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC₅₀=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518) .

HY-148535

Calpain Inhibitor XI	Proteasome	Neurological Disease
Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1. Calpain Inhibitor XI can be used for the research of neurodegenerative disorders .

HY-NP106

Highly purified Type XI collagen, from bovine articular cartilage Bovine Type xi collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-125986

GK187	Phospholipase	Neurological Disease
GK187 is a potent and selective Group VIA calcium-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an X_I(50) value of 0.0001. GK187 can be used for researching various neurological disorders . ^{[The X_I(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]}

HY-P991124

Cenvacibart 1 Publications Verification REGN-7508	Factor XI	Cardiovascular Disease
Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases .

HY-177669A

Vortosiran sodium	Factor XI	Metabolic Disease
Vortosiran sodium, a siRNA, is a blood coagulation factor XI synthesis reducer with anticoagulant activity.

HY-177669

Vortosiran	Factor XI	Metabolic Disease
Vortosiran, a siRNA, is a blood coagulation factor XI synthesis reducer with anticoagulant activity.

HY-N10126

(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid	Others	Others
(3ξ,4ξ,5ξ,6ξ,7ξ,11ξ)-3,6-Dihydroxy-8-oxo-9-eremophilene-12-oic acid is a new phytotoxin of Alternaria alternata ssp. tenuissima isolates associated with fruit spots on apple.

HY-186019

FtsZ-IN-14	Bacterial	Infection
FtsZ-IN-14 (example XI) is a filamentous temperature-sensitive protein Z (FtsZ) inhibitor. FtsZ-IN-14 can inhibit the growth of various drug-resistant bacteria in vitro and can be used to prepare antibiotics against drug-resistant bacteria .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Thrombin Factor Xa Autophagy Bacterial	Cardiovascular Disease Cancer
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-N0758R

Barlerin (Standard) 8-O-Acetyl shanzhiside methyl ester (Standard)	Caspase Reference Standards NF-κB	Inflammation/Immunology
Barlerin (Standard) is the analytical standard of Barlerin. This product is intended for research and analytical applications. Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt NF-κB.

HY-P5872

Jingzhaotoxin XI JZTX-xi	Sodium Channel	Neurological Disease
Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC₅₀ of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC₅₀=1.18±0.2 μM) of Na_v1.5 expressed in Chinese hamster ovary (CHO-K1) cells .

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM) .

HY-145568A

Feniralstat hydrochloride	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30) hydrochloride, a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM) .

HY-N14142

Citreamicin ξ	Bacterial	Infection
Citreamicin ξ has anti-Gram-positive aerobic and anaerobic bacterial activities .

HY-158677

BcI-2/BcI-xI ligand 1	Bcl-2 Family	Cancer
BcI-2/BcI-xI ligand 1 is a *BcI-2/BcI-xI* ligand, and can be used for synthesis of PROTAC BcI-2/BcI-xI Degrader-1 (HY-158551) .

HY-158551

PROTAC BcI-2/BcI-xI Degrader-1	PROTACs Bcl-2 Family	Cancer
PROTAC BcI-2/BcI-xI Degrader-1 (15) is a PROTAC based *BcI-2/BcI-xI* degrader (Red: BcI-2/BcI-xI inhibitor (HY-158677), black: linker, Blue: E3 ligase ligand) .

HY-N9327

3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid	Others	Inflammation/Immunology
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid, a lanostane-type triterpenoid, is isolated from Antrodia camphorate .

HY-N9725

16-Hydroxycleroda-3,13-dien-15,16-olide 16ξ-Hydroxycleroda-3,13-dien-15,16-olide	Dipeptidyl Peptidase	Metabolic Disease
16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy .

HY-112738

AX048	Phospholipase	Inflammation/Immunology
AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy .

HY-117610

Ro 31-8830 Ro 32-0432 free base; Bisindolylmaleimide xi	PKC	Inflammation/Immunology
Ro 31-8830 is an orally active, potent and selective inhibitor of protein kinase C with anti-inflammatory activity. Ro 31-8830 is promising for research of inflammatory disorders .

HY-158678

E3 ligase Ligand 27	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 27 (part of 15) is a ligand for E3 ligase, used for the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 (HY-158551)

HY-158679

E3 Ligase Ligand-linker Conjugate 110	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 110 is a E3 ligase ligand-linker conjugate, used for the synthesis of PROTAC BcI-2/BcI-xI Degrader-1 (HY-158551) .

HY-112935

Nonacog alfa BAX326; Coagulation factor IX [Recombinant]; BeneFIX	Ser/Thr Protease	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

HY-W091734

Methyl 4-iodo-L-phenylalaninate hydrochloride	Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .

HY-NP115

Highly purified Type XI collagen, from chick articular cartilage Chick Type xi collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-N17478

(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol	Drug Derivative	Others
(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Compound 7) is a polyoxygenated sterol isolated from the sponge Homaxinella sp.

HY-108638R

NSC 146109 hydrochloride (Standard) xi-011 hydrochloride (Standard)	Reference Standards MDM-2/p53 Apoptosis	Cancer
NSC 146109 hydrochloride (Standard) is the analytical standard of NSC 146109 (hydrochloride) (HY-108638). This product is intended for research and analytical applications. NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes .

HY-10780

JTV-803 mesylate	Endogenous Metabolite	Cardiovascular Disease
JTV-803 mesylate is a human factor Xa inhibitor with oral anticoagulant activity. JTV-803 exhibits competitive inhibition of human factor Xa, with a K_i value of 0.019μM and IC₅₀Value is 0.081μM. JTV-803 is 100 times more selective at inhibiting human factor Xa than its comparator. JTV-803 is an effective oral anticoagulant for the prevention of thrombosis .

HY-P992456

SAR-443809	Complement System	Cardiovascular Disease Endocrinology
SAR-443809 is a selective alternative complement system inhibitor and monoclonal antibody targeting complement factor Bb. SAR-443809 blocks the cleavage of C3 and factor B by selectively binding to the activated form of factor Bb, with a K_D of 7.3 nM for human factor Bb. SAR-443809 inhibits the amplification loop of the alternative complement pathway and C3 activation, reduces C3b deposition, and blocks the activation of pathways associated with intravascular and extravascular hemolysis. SAR-443809 can be used for the research of hematological and renal disorders mediated by abnormal alternative complement pathway .

Cat. No.	Product Name	Type

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Biochemical Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-NP126

Highly purified Type XI collagen, from porcine articular cartilage Porcine Type xi collagen, immunization grade	Biochemical Assay Reagents
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP106

Highly purified Type XI collagen, from bovine articular cartilage Bovine Type xi collagen, immunization grade	Biochemical Assay Reagents
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Biochemical Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-NP115

Highly purified Type XI collagen, from chick articular cartilage Chick Type xi collagen, immunization grade	Biochemical Assay Reagents
Highly purified Type XI collagen, from chick articular cartilage (Chick Type XI collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

Cat. No.	Product Name	Target	Research Area

HY-P5542

Vicatertide SB-01; Peniel 2000	Factor Xa TGF-beta/Smad	Inflammation/Immunology
Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a K_a of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases .

HY-P5872

Jingzhaotoxin XI JZTX-xi	Sodium Channel	Neurological Disease
Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor with an IC₅₀ of 124 nM. Jingzhaotoxin XI slows the fast inactivation (EC₅₀=1.18±0.2 μM) of Na_v1.5 expressed in Chinese hamster ovary (CHO-K1) cells .

HY-P1798

Platelet Factor 4 (58-70), human	Peptides	Cardiovascular Disease
Platelet Factor 4 (58-70), human, a peptide based on the amino acid sequence corresponding to residues 58-70 of platelet factor-4 (PF-4), contains the major heparin-binding domain, which is not sufficient for full antiangiogenic activity .

HY-W091734

Methyl 4-iodo-L-phenylalaninate hydrochloride	Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991124

Cenvacibart 1 Publications Verification REGN-7508	Factor XI	Cardiovascular Disease
Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases .

HY-112935

Nonacog alfa BAX326; Coagulation factor IX [Recombinant]; BeneFIX	Ser/Thr Protease	Others
Nonacog alfa (BAX326) is a recombinant human factor IX that can be used for the research of haemophilia B .

HY-P992456

SAR-443809	Complement System	Cardiovascular Disease Endocrinology
SAR-443809 is a selective alternative complement system inhibitor and monoclonal antibody targeting complement factor Bb. SAR-443809 blocks the cleavage of C3 and factor B by selectively binding to the activated form of factor Bb, with a K_D of 7.3 nM for human factor Bb. SAR-443809 inhibits the amplification loop of the alternative complement pathway and C3 activation, reduces C3b deposition, and blocks the activation of pathways associated with intravascular and extravascular hemolysis. SAR-443809 can be used for the research of hematological and renal disorders mediated by abnormal alternative complement pathway .

Species:	Human (2) Cynomolgus (1) Rabbit (1)
Tag:	His (4)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700978

	*Coagulation Factor* XI/F11 Protein, Cynomolgus (HEK293, His)** Fxi; PTA; F11; Coagulation factor xi	Cynomolgus	HEK293
	Coagulation factor XI (F11) occupies a central position in the middle phase of the intrinsic pathway of blood coagulation, where it assumes the key role of activating factor IX. This complex process plays a key role in the chain of events that lead to the formation of a blood clot. Coagulation Factor XI/F11 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Coagulation Factor XI/F11 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703948

	*Coagulation Factor* XI/F11 Protein, Rabbit (HEK293, His)** Coagulation factor xi; Fxi; PTA; F11	Rabbit	HEK293
	Coagulation Factor XI/F11 Protein, Rabbit (HEK293, His) is the recombinant rabbit-derived Coagulation Factor XI/F11 protein, expressed by HEK293, with C-His tag.

HY-P73046

	*Coagulation Factor* XI/F11 Protein, Human (HEK293, His)** Coagulation factor xi; Coagulation factor xia light chain; PTA; Fxi; F11	Human	HEK293
	Coagulation factor XI (F11) occupies a central position in the middle phase of the intrinsic pathway of blood coagulation, where it assumes the key role of activating factor IX. This complex process plays a key role in the chain of events that lead to the formation of a blood clot. Coagulation Factor XI/F11 Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XI/F11 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7729

	*Carbonic Anhydrase 11 Protein, Human* (HEK293, His)** rHuCarbonic Anhydrase 11, His; Carbonic Anhydrase-Related Protein 11; CARP xi; Carbonic Anhydrase-Related Protein 2; CA-RP II; CA11; CARP2	Human	HEK293
	Carbonic Anhydrase 11 Protein, Human (HEK293, His) is an approximately 38.0 kDa carbonic anhydrase 11 protein with a His-flag. Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	WB FC ICC/IF (1) WB (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810466

	Collagen XI A1 Antibody (YA9765) COL11A1, Collagen Type xi Alpha 1 Chain, CO11A1, COLL6, STL2, Collagen xi, Alpha-1 Polypeptide, Deafness, Autosomal Dominant 37, Collagen, Type xi, Alpha 1, Collagen Alpha-1(xi) Chain, DFNA37	WB FC ICC/IF	Human
	Collagen XI A1 Antibody (YA9765) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Collagen XI A1.

HY-P82231

	Collagen XI A1 Antibody (YA1976) COL11A1; COLL6; Collagen alpha-1(xi) chain	WB	Human
	Collagen XI A1 Antibody (YA1976) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen XI A1.

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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human-factor-xi

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products