1. Cell Cycle/DNA Damage
    PROTAC
  2. CDK
    PROTAC
  3. JH-XI-10-02

JH-XI-10-02 

Cat. No.: HY-111518
Handling Instructions

JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

For research use only. We do not sell to patients.

JH-XI-10-02 Chemical Structure

JH-XI-10-02 Chemical Structure

CAS No. : 2209085-22-1

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Description

JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].

IC50 & Target[1]

CDK8

159 nM (IC50)

PROTAC

 

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

920.14

Formula

C₅₃H₆₉N₅O₉

CAS No.

2209085-22-1

SMILES

O=C(N([[email protected]]1CC[[email protected]]2(C)C3CC[[email protected]]4(C)[[email protected]@H](C5=CC6=C(C=C5)C=CN=C6)CC[[email protected]@]4([H])[[email protected]]3([H])CCC2C1)C)CCOCCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
JH-XI-10-02
Cat. No.:
HY-111518
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JH-XI-10-02

Cat. No.: HY-111518