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Vortosiran

(Synonyms: RBD4059)

Vortosiran (RBD4059) is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran is internalized via ASGPR-mediated endocytosis, subsequently regulating mRNA translation to suppress FXI synthesis. Vortosiran exhibits antithrombotic activity without impairing hemostatic function. Vortosiran can be used in research related to intravascular thrombosis.

For research use only. We do not sell to patients.

  • Purity : 97.76%
  • CAS No.: 3061406-99-0
  • Formula: C463H620F7N154O291P39S6
  • Molecular Weight:14532.10
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Vortosiran Chemical Structure
    Vortosiran Chemical Structure
CAS No.: 3061406-99-0
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  • Vortosiran Chemical Structure
    Vortosiran Chemical Structure RNA, (Cm-sp-(2'-deoxy-2'-fluoro)A-sp-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Cm-Cm-Am-Gm-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)G-Um-Am-Cm-sp-Um-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-Cm-Gm-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-Cm-Um-Gm-Gm-Am-Um-Um-Cm-Um-Gm) 3'-[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]propyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-2-hydroxy-3-oxopropyl hydrogen phosphate] (1:1)
    1/16
  • RNA, (Cm-sp-(2'-deoxy-2'-fluoro)A-sp-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Cm-Cm-Am-Gm-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)G-Um-Am-Cm-sp-Um-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-Cm-Gm-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-Cm-Um-Gm-Gm-Am-Um-Um-Cm-Um-Gm) 3'-[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]propyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-2-hydroxy-3-oxopropyl hydrogen phosphate] (1:1)