1. Apoptosis
  2. MDM-2/p53
  3. NSC-207895

NSC-207895 (Synonyms: XI-006)

Cat. No.: HY-14714
Handling Instructions

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

For research use only. We do not sell to patients.

NSC-207895 Chemical Structure

NSC-207895 Chemical Structure

CAS No. : 58131-57-0

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Description

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].

In Vitro

NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels[2].
NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels[3].

Western Blot Analysis[2]

Cell Line: RAW 264.7 cells.
Concentration: 0.5 μM.
Incubation Time: 30 min (stimulated with LPS (100 ng/ml) for 6 h).
Result: Upregulated p53 protein levels.
Molecular Weight

279.25

Formula

C₁₁H₁₃N₅O₄

CAS No.

58131-57-0

SMILES

O=[N+](C1=CC=C(N2CCN(C)CC2)C3=[N+]([O-])ON=C31)[O-]

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NSC-207895XI-006NSC207895NSC 207895XI006XI 006MDM-2/p53p53MDM2MDMXLPSInhibitorinhibitorinhibit

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