1. Apoptosis
  2. MDM-2/p53
  3. NSC-207895

NSC-207895  (Synonyms: XI-006)

Cat. No.: HY-14714 Purity: 98.97%
COA Handling Instructions

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

For research use only. We do not sell to patients.

NSC-207895 Chemical Structure

NSC-207895 Chemical Structure

CAS No. : 58131-57-0

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5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
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25 mg USD 550 In-stock
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100 mg USD 1280 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].

In Vitro

NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels[2].
NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: RAW 264.7 cells.
Concentration: 0.5 μM.
Incubation Time: 30 min (stimulated with LPS (100 ng/ml) for 6 h).
Result: Upregulated p53 protein levels.
Molecular Weight









Room temperature in continental US; may vary elsewhere.


4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (111.91 mM; ultrasonic and warming and heat to 60°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5810 mL 17.9051 mL 35.8102 mL
5 mM 0.7162 mL 3.5810 mL 7.1620 mL
10 mM 0.3581 mL 1.7905 mL 3.5810 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (7.45 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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