country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-158551

Copy Link Print Information

PROTAC BcI-2/BcI-xI Degrader-1

PROTAC Bcl-2/Bcl-xL Degrader-1 is a Bcl-2/Bcl-xL PROTAC degrader with a DC₅₀ of 11.28 nM against Bcl-xL. PROTAC Bcl-2/Bcl-xL Degrader-1 promotes ubiquitination and degradation of Bcl-2/Bcl-xL. It exhibits anticancer activity against acute lymphoblastic leukemia. PROTAC Bcl-2/Bcl-xL Degrader-1 can be used in the research of BCL-2-mediated or BCL-2-dependent diseases.
(Pink: Bcl-2 and Bcl-xL ligand (HY-158677); Blue: VHL ligand (HY-158678); Black: linker (HY-Y1139)).

For research use only. We do not sell to patients.

CAS No.: 3034200-49-9
Formula: C₇₈H₉₄ClF₃N₁₀O₁₂S₄
Molecular Weight:1584.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC BcI-2/BcI-xI Degrader-1 Chemical Structure

CAS No.: 3034200-49-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC Bcl-2/Bcl-xL Degrader-1 is a Bcl-2/Bcl-xL PROTAC degrader with a DC₅₀ of 11.28 nM against Bcl-xL. PROTAC Bcl-2/Bcl-xL Degrader-1 promotes ubiquitination and degradation of Bcl-2/Bcl-xL. It exhibits anticancer activity against acute lymphoblastic leukemia. PROTAC Bcl-2/Bcl-xL Degrader-1 can be used in the research of BCL-2-mediated or BCL-2-dependent diseases^[1]. (Pink: Bcl-2 and Bcl-xL ligand (HY-158677); Blue: VHL ligand (HY-158678); Black: linker (HY-Y1139)).

IC₅₀ & Target^[1]

Bcl-xL

11.28 nM (DC₅₀)

Bcl-2

VHL

All PROTACs Isoforms :

All Bcl-2 Family Isoforms :

In Vitro

PROTAC BcI-2/BcI-xI Degrader-1 (Compound 15) inhibits the binding of BCL-xL to Bim with a K_i value of 0.55 nM in cell-free biochemical assays^[1].
PROTAC BcI-2/BcI-xI Degrader-1 inhibits the binding of BCL-2 to Bim with a K_i value of 0.81 nM in cell-free biochemical assays^[1].
PROTAC Bcl-2/Bcl-xL Degrader-1 degrades Bcl-xL in MOLT-4 cells with a DC₅₀ of 11.28 nM^[1].
PROTAC Bcl-2/Bcl-xL Degrader-1 inhibits the proliferation of MOLT-4 cells with an IC₅₀ of 13.43 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034200-49-9
Molecular Weight 1584.35
Formula C₇₈H₉₄ClF₃N₁₀O₁₂S₄
SMILES

O=S(NC(C1=CC=C(N2[C@@](CO3)([H])CN(CC2)CC4=C(C5=CC=C(C=C5)Cl)CCC(C)(C4)C)C3=C1)=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCN(CC8)C(CCCCCC(N[C@@H](C(C)(C)C)C(N9[C@@H](C[C@H](C9)O)C(NCC%10=CC=C(C%11=C(N=CS%11)CCO%12)C%12=C%10)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dongping, et al. Chimeric compound used for targeted degradation of bcl-2 protein, preparation method therefor, and pharmaceutical application thereof. Patent. WO2024067818A1. WIPO (PCT). 2023-09-28.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC BcI-2/BcI-xI Degrader-1

All PROTACs Isoforms

All Bcl-2 Family Isoforms