3034200-49-9
Chemical Structure
PROTAC BcI-2/BcI-xI Degrader-1
- CAS No.: 3034200-49-9
- Formula:C78H94ClF3N10O12S4
- Molecular Weight:1584.35
InChIKey: HUTJHTKYOWKSDW-ZDAWVCBKSA-N
SMILES: O=S(NC(C1=CC=C(N2[C@@](CO3)([H])CN(CC2)CC4=C(C5=CC=C(C=C5)Cl)CCC(C)(C4)C)C3=C1)=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCN(CC8)C(CCCCCC(N[C@@H](C(C)(C)C)C(N9[C@@H](C[C@H](C9)O)C(NCC%10=CC=C(C%11=C(N=CS%11)CCO%12)C%12=C%10)=O)=O)=O)=O)=O
Biological Activity: PROTAC Bcl-2/Bcl-xL Degrader-1 is a Bcl-2/Bcl-xL PROTAC degrader with a DC50 of 11.28 nM against Bcl-xL. PROTAC Bcl-2/Bcl-xL Degrader-1 promotes ubiquitination and degradation of Bcl-2/Bcl-xL. It exhibits anticancer activity against acute lymphoblastic leukemia. PROTAC Bcl-2/Bcl-xL Degrader-1 can be used in the research of BCL-2-mediated or BCL-2-dependent diseases[1].
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PROTAC BcI-2/BcI-xI Degrader-1 | PROTAC Bcl-2/Bcl-xL Degrader-1 is a Bcl-2/Bcl-xL PROTAC degrader with a DC50 of 11.28 nM against Bcl-xL. PROTAC Bcl-2/Bcl-xL Degrader-1 promotes ubiquitination and degradation of Bcl-2/Bcl-xL. It exhibits anticancer activity against acute lymphoblastic leukemia. PROTAC Bcl-2/Bcl-xL Degrader-1 can be used in the research of BCL-2-mediated or BCL-2-dependent diseases. | |||||||||||||||||||||
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Keywords
