JH-VIII-49
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518).
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- CAS No.: 2209084-73-9
- Formule: C30H40N2
- Masse moléculaire:428.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK8 16 nM (IC50) |
Chemical Information
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CAS No. 2209084-73-9
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Masse moléculaire 428.65
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Formule C30H40N2
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SMILES
C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JH-VIII-49 Related Classifications
HY-125001 Related Classifications
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