JH-VIII-49
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2209084-73-9
- Fòrmula: C30H40N2
- Peso molecular:428.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
CDK8 16 nM (IC50) |
Chemical Information
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No. CAS 2209084-73-9
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Peso molecular 428.65
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Fòrmula C30H40N2
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SMILES
C[C@@]12[C@](CC[C@@H]2C3=CC4=C(C=CN=C4)C=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@H](CC6)N(C)C)=CC5)C)([H])CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JH-VIII-49 Related Classifications
HY-125001 Related Classifications
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