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Vortosiran sodium

(Synonyms: RBD4059 sodium)

Vortosiran (RBD4059) sodium is a siRNA that inhibits the synthesis of coagulation factor XI (FXI). Vortosiran sodium shows potent inhibitory activity against mouse FXI transcripts with an IC50 of 69 pM; it exerts similar effects on common FXI transcripts from humans and monkeys, with an IC50 of 59 pM. Vortosiran sodium exhibits antithrombotic activity without impairing hemostatic function. Vortosiran sodium can be used in research related to intravascular thrombosis.

For research use only. We do not sell to patients.

  • Formula: C463H580F7N154Na40O291P39S6
  • Molecular Weight:15411.30
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Vortosiran sodium Chemical Structure
    Vortosiran sodium Chemical Structure
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  • Vortosiran sodium Chemical Structure
    Vortosiran sodium Chemical Structure RNA, (Cm-sp-(2'-deoxy-2'-fluoro)A-sp-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Cm-Cm-Am-Gm-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)G-Um-Am-Cm-sp-Um-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-Cm-Gm-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-Cm-Um-Gm-Gm-Am-Um-Um-Cm-Um-Gm) 3'-[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]propyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-2-hydroxy-3-oxopropyl hydrogen phosphate] (1:1), sodium salt
    1/16
  • RNA, (Cm-sp-(2'-deoxy-2'-fluoro)A-sp-Gm-Am-Am-(2'-deoxy-2'-fluoro)U-Cm-Cm-Am-Gm-Um-Cm-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)G-Um-Am-Cm-sp-Um-sp-Um), complex with RNA (Gm-sp-Um-sp-Am-Cm-Gm-Um-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-Cm-Um-Gm-Gm-Am-Um-Um-Cm-Um-Gm) 3'-[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]propyl][3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-2-hydroxy-3-oxopropyl hydrogen phosphate] (1:1), sodium salt