2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Bacterial Antibiotic
  4. Questiomycin A

Questiomycin A  (Synonyms: Phx-3)

製品番号: HY-N8439 純度: 99.00%
COA 取扱説明書 Technical Support

Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases.

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Questiomycin A

Questiomycin A 構造式

CAS 番号 : 1916-59-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 88 在庫あり
Solution
10 mM * 1 mL in DMSO USD 88 在庫あり
Solid
5 mg $80 在庫あり
10 mg $130 在庫あり
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100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Questiomycin A 関連抗体

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製品説明

Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].

IC50 & Target

Grp78

 

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
2 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute T-lymphoblastic leukemia CCRF-CEM cells by 50%, using MTT method
[PMID: 12431048]
CCRF-SB IC50
1 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of human acute B-lymphoblastic leukemia CCRF-SB cells by 50%, using MTT method
[PMID: 12431048]
HEp-2 IC50
1.8 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of larynx carcinoma cells by 50%, using MTT method
[PMID: 12431048]
HeLa IC50
2.7 μM
Compound: 1
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
Compound concentration required to reduce the cell proliferation of cervix carcinoma Hela cells by 50%, using MTT method
[PMID: 12431048]
HepG2 GI50
0.61 μM
Compound: 2-aminophenoxazinone
Cytotoxicity against human Hep G2 cells
Cytotoxicity against human Hep G2 cells
[PMID: 16933866]
HepG2 GI50
6.6 μM
Compound: 2-aminophenoxazinone
Cytotoxicity against human Hep G2 cells
Cytotoxicity against human Hep G2 cells
[PMID: 16933866]
体外実験

Questiomycin A (3 µM; 24 h) induces cell death and downregulates GRP78 protein expression in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Questiomycin A 関連抗体

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 3 µM
Incubation Time: 24 h
Result: Suppressed more than 50% of the GRP78 expression and induced cell death.
体内実験

Questiomycin A (10 mg/kg; i.p.; once a day for 8 days) enhances the antitumor effect of Sorafenib by stimulating the downregulation of GRP78 in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (HepG2 cells xenograft model)[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once a day; 8 days.
Result: Stimulated Sorafenib-dependent antitumor activity.
分子量

212.20

分子式

C12H8N2O2
CAS 番号
Appearance

Solid

Color

Brown to black

SMILES

O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 12.5 mg/mL (58.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.00%

COA (248 KB) HNMR (373 KB) RP-HPLC (258 KB) LCMS (105 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7125 mL 23.5627 mL 47.1254 mL 117.8134 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL 23.5627 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL 11.7813 mL
15 mM 0.3142 mL 1.5708 mL 3.1417 mL 7.8542 mL
20 mM 0.2356 mL 1.1781 mL 2.3563 mL 5.8907 mL
25 mM 0.1885 mL 0.9425 mL 1.8850 mL 4.7125 mL
30 mM 0.1571 mL 0.7854 mL 1.5708 mL 3.9271 mL
40 mM 0.1178 mL 0.5891 mL 1.1781 mL 2.9453 mL
50 mM 0.0943 mL 0.4713 mL 0.9425 mL 2.3563 mL
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Questiomycin A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Questiomycin A1916-59-2Phx-3Phx3Phx 3HSPBacterialAntibioticHeat shock proteinsHCCcancertumorbacteriaPseudomonas chlororaphisHepG2Hep3BU2OSHuH-7infectionInhibitorinhibitorinhibit

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製品番号:
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