1916-59-2
1916-59-2
Chemical Structure
Questiomycin A
Synonym(s): Phx-3
- CAS No.: 1916-59-2
- Formula:C12H8N2O2
- Molecular Weight:212.20
IUPAC Name: 2-amino-3H-phenoxazin-3-one
InChIKey: RDJXPXHQENRCNG-UHFFFAOYSA-N
SMILES: O=C1C(N)=CC2=NC3=C(C=CC=C3)OC2=C1
Biological Activity: Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Questiomycin A | 98.16% | Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases. | ||||||||||||||||||||
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References
- [1]. Machihara K, et al. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem Biophys Res Commun. 2017 Oct 7;492(1):33-40. [Content Brief]
- [2]. Guo S, et al. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. J Agric Food Chem. 2022 Jun 29;70(25):7742-7750. [Content Brief]
