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Results for "

α-glucosidase. Antioxidant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amylases (4) Amyloid-β (1) Apoptosis (2) Aurora Kinase (1) c-Kit (1) Carbonic Anhydrase (1) Cholinesterase (ChE) (3) COX (2) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (1) Endogenous Metabolite (6) Estrogen Receptor/ERR (2) Glutathione Peroxidase (2) Glycosidase (29) HBV (2) HDAC (1) Isotope-Labeled Compounds (1) JNK (1) MMP (1) Monoamine Oxidase (3) NF-κB (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Phosphodiesterase (PDE) (2) PPAR (3) Pregnane X Receptor (PXR) (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Tyrosinase (3) VEGFR (1) β-glucuronidase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (3) Endocrinology (1) Infection (4) Inflammation/Immunology (6) Metabolic Disease (20) Neurological Disease (8)

By Targets:

Amylases (4)

Amyloid-β (1)

Apoptosis (2)

Aurora Kinase (1)

c-Kit (1)

Carbonic Anhydrase (1)

Cholinesterase (ChE) (3)

COX (2)

Dipeptidyl Peptidase (2)

DNA/RNA Synthesis (1)

Endogenous Metabolite (6)

Estrogen Receptor/ERR (2)

Glutathione Peroxidase (2)

Glycosidase (29)

HBV (2)

HDAC (1)

Isotope-Labeled Compounds (1)

JNK (1)

MMP (1)

Monoamine Oxidase (3)

NF-κB (1)

NOD-like Receptor (NLR) (1)

p38 MAPK (1)

Phosphodiesterase (PDE) (2)

PPAR (3)

Pregnane X Receptor (PXR) (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

Tyrosinase (3)

VEGFR (1)

β-glucuronidase (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (6)

Metabolic Disease (20)

Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132179

Fucoidan 5+ Cited Publications	Glycosidase	Cardiovascular Disease Metabolic Disease Cancer
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .

HY-N0058

4,5-Dicaffeoylquinic acid Maximum Cited Publications 11 Publications Verification Isochlorogenic acid C	HBV Endogenous Metabolite Apoptosis Glycosidase	Infection
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast *α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis* B virus effects .

HY-N0464

D-(-)-Quinic acid 3 Publications Verification	Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-126052

Gnetol	COX Tyrosinase HDAC	Metabolic Disease Cancer
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N0419

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Glycosidase c-Kit MMP VEGFR Aurora Kinase	Metabolic Disease Cancer
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

HY-N1029

Norathyriol 3 Publications Verification Mangiferitin	Glycosidase PPAR	Infection Inflammation/Immunology Cancer
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits *α-glucosidase* in a noncompetitive manner with an IC₅₀ of 3.12 μM . Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC₅₀s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

HY-N2025

Oroxin A 4 Publications Verification	PPAR Glycosidase	Metabolic Disease
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against *α-glucosidase* and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N2278

Kushenol A 4 Publications Verification Leachianone E	Tyrosinase Glycosidase	Cancer
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N8220

2-(2-Phenylethyl)chromone Flidersiachromone	Glycosidase	Neurological Disease Cancer
2-(2-Phenylethyl) chromone (Flidersiachromone) is a chromone derivative and *antioxidant. 2-(2-Phenylethyl) chromone scavenges ABTS· ⁺ free radicals, and its derivatives exhibit diverse activities including anti-inflammatory, neuroprotective, anti-tumor, and α-glucosidase* inhibitory effects. 2-(2-Phenylethyl) chromone is applicable to experimental research in fields such as inflammation-related diseases, tumors, and neurodegenerative diseases .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Cancer
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N0058R

4,5-Dicaffeoylquinic acid (Standard) Isochlorogenic acid C (Standard)	Reference Standards HBV Endogenous Metabolite Apoptosis Glycosidase	Infection
4,5-Dicaffeoylquinic acid (Standard) is the analytical standard of 4,5-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects .

HY-N9454

Garcinoic acid	Pregnane X Receptor (PXR) COX NF-κB Amylases β-glucuronidase DNA/RNA Synthesis Amyloid-β NOD-like Receptor (NLR) Pyroptosis	Cancer
Garcinoic acid is an orally active anti-inflammatory agent that crosses the blood-brain barrier. Garcinoic acid also enhances efferocytosis and enzyme/receptor regulation, and selectively inhibits human COX-2, porcine α-amylase, Saccharomyces cerevisiae *α-glucosidase* and human DNA polymerase β (IC₅₀=11 μM), as well as activates human PXR. Garcinoic acid enhances macrophage efferocytosis via receptors such as MerTK and LRP-1, and promotes the production of pro-resolving lipid mediators. Garcinoic acid inhibits NF-κB activation and pro-inflammatory cytokine secretion, interferes with Aβ aggregation, downregulates NLRP3 inflammasome activity, and binds to targets including CD44 and EGFR to inhibit leukemia cell proliferation. The pharmacological activities of Garcinoic acid, such as antioxidant, anti-inflammatory and lipid metabolism-regulating effects, are widely used in studies related to various diseases including atherosclerosis, Alzheimer's disease, type 2 diabetes, inflammatory bowel disease and viral pneumonia .

HY-N3078

p-Hydroxyphenethyl trans-ferulate	Glycosidase	Endocrinology Cancer
p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast *α-glucosidase, IC₅₀=19.24 ± 1.73 µM), antioxidant, and anti*-inflammatory activities . p-Hydroxyphenethyl trans-ferulate shows inhibiting anticancer and serotonergic activity .

HY-N0464S

Quinic acid-13C3	Isotope-Labeled Compounds Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
Quinic acid- ¹³C₃ is the ¹³C-labeled D-(-)-Quinic acid. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N16523

Ferruginoside C	Glycosidase	Cancer
Ferruginoside C is a phenylethanoid. Ferruginoside C can be isolated from V. leiocarpum. Ferruginoside C shows potent *alpha-glucosidase* inhibitory activity with an IC₅₀ of 19.93 μM. Ferruginoside C shows antioxidant activities. Ferruginoside C can be used in the research of cervical cancer, ovarian cancer, and colon cancer .

HY-N15138

Sativanone	Glycosidase	Infection Metabolic Disease Inflammation/Immunology
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent *α-glucosidase* inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-162639

α-Glucosidase-IN-68	Glycosidase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
α-Glucosidase-IN-68 (Compound 2) is an inhibitor for *α-Glucosidase, AChE, and BChE, with IC₅₀* of 0.251, 0.774 and 0.793 μM, respectively. α-Glucosidase-IN-68 exhibits antioxidant efficacy, with IC₅₀ of 0.69 μM and 0.02 μM, in DPPH and ABTS experiments. α-Glucosidase-IN-68 exhibits antidiabetic effect in Streptozotocin (HY-13753)-induced diabetic rat models .

HY-162169

α-Amylase/α-Glucosidase-IN-8	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-8 (Compound 7p) is a potent dual inhibitor of α-amylase and *α-glucosidase, with IC₅₀s* of 10.19 and 10.33 μM, respectively. α-Amylase/α-Glucosidase-IN-8 has good anti-oxidant activity(IC₅₀ = 14.93 μM). α-Amylase/α-Glucosidase-IN-8 can be used for the research of diabetes .

HY-N12138

Flaccidoside III	Glycosidase	Metabolic Disease
Flaccidoside III is a triterpenoid isolated from the aerial parts of N. sativa (Ranunculaceae). Flaccidoside III inhibits α-Glucosidase (IC₅₀: 256.7 μM) and has potential antioxidant and antidiabetic activities .

HY-N7729

Sekikaic acid	Amylases Glycosidase	Metabolic Disease
Sekikaic acid is an α-glucosidase (Glucosidase) and α-amylase (Amylases) inhibitor with hypolipidemic, antioxidant and antidiabetic activities. Sekikaic acid significantly reduces LDL, total cholesterol, and total glyceride levels and causes pancreatic beta cell regeneration .

HY-N1186

Tachioside	Glycosidase	Metabolic Disease
Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC₅₀ value of 12.14 μM. Tachioside has anti-obesity, antioxidant and *α-glucosidase* inhibitory activities .

HY-163335

MPO-IN-7	Glutathione Peroxidase Dipeptidyl Peptidase Glycosidase	Cardiovascular Disease Inflammation/Immunology
MPO-IN-7 (compound MDC) is a myeloperoxidase inhibitor with the IC₅₀ values of 41 μM, 25 μM and 4.5 μM towards α-Glucosidase, dipeptidyl peptidase-4 and myeloperoxidase, respectively. MPO-IN-7 shows antioxidant and anti-inflammatory activity in vitro .

HY-19602

Cedefingol	Endogenous Metabolite	Cancer
Cedefingol is an antitumor compound with α-glucosidase inhibitory activity. Cedefingol was identified together with other compounds in fermented dark tea samples. The biotransformation of cedefingol is related to enzymatic hydrolysis, hydrolysis and biosynthesis. Cedefingol exhibited different bioactivities in samples with different fermentation times. The antioxidant properties of cedefingol showed certain activity in the DPPH model .

HY-N0464R

D-(-)-Quinic acid (Standard)	Reference Standards Endogenous Metabolite Glycosidase Monoamine Oxidase	Neurological Disease Metabolic Disease
D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and *α-Glucosidase* (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active .

HY-N9283

1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran	Reactive Oxygen Species (ROS)	Neurological Disease Cancer
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC₅₀ of 28 μM, inhibits malondialdehyde (MDA) with the IC₅₀ of 71 μM, and inhibits α-glucosidase with the IC₅₀ of 6.22 μM .

HY-163332

MPO-IN-6	Glycosidase Dipeptidyl Peptidase Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC₅₀s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent .

HY-N2025R

Oroxin A (Standard)	Reference Standards PPAR Glycosidase	Metabolic Disease
Oroxin A (Standard) is the analytical standard of Oroxin A. This product is intended for research and analytical applications. Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence .

HY-N2168R

Pinoresinol 4-O-β-D-glucopyranoside (Standard) (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)	Glycosidase Reference Standards Estrogen Receptor/ERR Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Cancer
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-173130

α-Glucosidase-IN-86	Glycosidase	Metabolic Disease Inflammation/Immunology
α-Glucosidase-IN-86 (Compound A4) is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 2.72 μM. α-Glucosidase-IN-86 has high safety in mice. α-Glucosidase-IN-86 can reduce fasting blood glucose levels, improve glucose tolerance, regulate blood lipids, and has antioxidant effects in diabetic mice. α-Glucosidase-IN-86 can be used for the research of diabetes .

HY-181353

α-Glucosidase-IN-112	Glycosidase	Metabolic Disease Cancer
α-Glucosidase-IN-112 is an *α-glucosidase* inhibitor with an IC₅₀ of 2.03 μM and a K_i of 0.44 μM. α-Glucosidase-IN-112 exerts antioxidant effects by scavenging ABTS ⁺ free radicals. α-Glucosidase-IN-112 exerts antiproliferative effects by inhibiting the proliferation of bladder cancer cells. α-Glucosidase-IN-112 can be used in research related to type 2 diabetes and bladder cancer .

HY-N17215

3,4,6-Tri-O-galloyl-D-glucose 3,4,6-Trigalloylglucose	Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
3,4,6-Tri-O-galloyl-D-glucose (3,4,6-Trigalloylglucose) is an α-amylase (porcine α-amylase IC₅₀ = 334.6 μM; K_i = 307.5 μM) and *α-glucosidase* (*yeast α-glucosidase* IC₅₀ = 46.5 μM; K_i** = 39.9 μM) mixed type inhibitor. 3,4,6-Tri-O-galloyl-D-glucose exhibits free radical scavenging ability, ferric-reducing power, and antioxidant activity. 3,4,6-Tri-O-galloyl-D-glucose can be used for the research of diabetes .

HY-N19401

Vescalagin	Cholinesterase (ChE) Carbonic Anhydrase Glycosidase JNK p38 MAPK	Metabolic Disease Inflammation/Immunology
Vescalagin is a hexahydroxyphenol. Vescalagin is isolable from Camu-camu (Myrciaria dubia) and immature wax apple fruits. Vescalagin exhibits inhibitory activity against a variety of enzymes, with a K_i value of 5.87 nM against AChE, 3.89 nM against BChE, 11.75 nM against hCA I, 16.23 nM against hCA II, and 16.08 nM against *α-glucosidase. Vescalagin inhibits hCA I, hCA II and α-glucosidase* in a non-competitive manner. Vescalagin downregulates JNK/p38 MAPK to protect pancreatic β-cells and improve insulin secretion in methylglyoxal-treated rats. Vescalagin reduces hyperglycemia and hypertriglyceridemia in rats fed a high-fructose diet. Vescalagin possesses anti-inflammatory and antioxidant properties .

HY-180506

Tyrosinase-IN-47	Tyrosinase Glycosidase Cholinesterase (ChE)	Others
Tyrosinase-IN-47 (compound 6a) is a potent competitive tyrosinase inhibitor with an IC₅₀ of 1.43 µM and a K_i of 0.1142 μM. Tyrosinase-IN-47 also shows inhibition activity in *α-Glucosidase* (IC₅₀ = 36.26 μM) and acetylcholinesterase (IC₅₀ = 8.26 μM). Tyrosinase-IN-47 exhibits in vitro antioxidant activity, with good scavenging ability for DPPH (IC₅₀ = 4.75 μM) and ABTS (IC₅₀ = 0.04 μM). Tyrosinase-IN-47 displays anti-browning effect on freshly cut potatoes. Tyrosinase-IN-47 can be used for pharmaceutical research .

Cat. No.	Product Name	Category	Target	Chemical Structure