2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-112

α-Glucosidase-IN-112 is an α-glucosidase inhibitor with an IC50 of 2.03 μM and a Ki of 0.44 μM. α-Glucosidase-IN-112 exerts antioxidant effects by scavenging ABTS+ free radicals. α-Glucosidase-IN-112 exerts antiproliferative effects by inhibiting the proliferation of bladder cancer cells. α-Glucosidase-IN-112 can be used in research related to type 2 diabetes and bladder cancer.

For research use only. We do not sell to patients.

α-Glucosidase-IN-112

α-Glucosidase-IN-112 Chemical Structure

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α-Glucosidase-IN-112 Related Antibodies

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Description

α-Glucosidase-IN-112 is an α-glucosidase inhibitor with an IC50 of 2.03 μM and a Ki of 0.44 μM. α-Glucosidase-IN-112 exerts antioxidant effects by scavenging ABTS+ free radicals. α-Glucosidase-IN-112 exerts antiproliferative effects by inhibiting the proliferation of bladder cancer cells. α-Glucosidase-IN-112 can be used in research related to type 2 diabetes and bladder cancer[1].

IC50 & Target[1]

α‑glucosidase

2.03 μM (IC50)

α‑glucosidase

0.44 μM (Ki)

In Vitro

α-Glucosidase-IN-112 (Compound 4i) (0-2.0 μM; 24 h) potently inhibits the proliferation of human T24 bladder cancer cells with an IC50 of 1.93 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-112 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: human T24 bladder cancer cells
Concentration: 0, 0.5, 1, 1.5 and 2.0 μM
Incubation Time: 24 h
Result: Inhibited T24 bladder cancer cell proliferation with an IC50 value of 1.93 μM, which is lower than the IC50 value of the positive control cisplatin.
Molecular Weight

466.58

Formula

C23H22N4O3S2
SMILES

O=S(C1=CC=C(/C(C)=N/NC(C2=CNC3=C2C=CC=C3)=O)C=C1)(NCCC4=CC=CS4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-112 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-112Glycosidasetype-2 diabetesSaccharomyces cerevisiaebladder cancer cellsα-glucosidaseMM/PBSA binding free energybladder cancerhuman T24 bladder cancer cellsamino acid residuesABTS+ free radicalsactive siteInhibitorinhibitorinhibit

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α-Glucosidase-IN-112
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HY-181353
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