Search Result

Results for "

AT1 receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Angiotensin Receptor (89) Angiotensin-converting Enzyme (ACE) (1) Apelin Receptor (APJ) (1) Apoptosis (11) Autophagy (6) Calcium Channel (1) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (2) Endothelin Receptor (2) ERK (1) Isotope-Labeled Compounds (9) MMP (1) Neprilysin (2) NF-κB (1) p38 MAPK (1) PPAR (2) Reactive Oxygen Species (ROS) (3) Reference Standards (11) TGF-beta/Smad (1) TGF-β Receptor (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (75) Endocrinology (36) Inflammation/Immunology (6) Metabolic Disease (9) Neurological Disease (9)

By Targets:

5-HT Receptor (1)

Angiotensin Receptor (89)

Angiotensin-converting Enzyme (ACE) (1)

Apelin Receptor (APJ) (1)

Apoptosis (11)

Autophagy (6)

Calcium Channel (1)

Drug Derivative (2)

Drug Intermediate (1)

Drug Metabolite (2)

Endogenous Metabolite (2)

Endothelin Receptor (2)

ERK (1)

Isotope-Labeled Compounds (9)

MMP (1)

Neprilysin (2)

NF-κB (1)

p38 MAPK (1)

PPAR (2)

Reactive Oxygen Species (ROS) (3)

Reference Standards (11)

TGF-beta/Smad (1)

TGF-β Receptor (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (75)

Endocrinology (36)

Inflammation/Immunology (6)

Metabolic Disease (9)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17512

Losartan Maximum Cited Publications 54 Publications Verification DuP-753	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-13955

Telmisartan 15+ Cited Publications BIBR 277	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17512A

Losartan potassium Maximum Cited Publications 54 Publications Verification DuP-753 potassium	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-B0202

Irbesartan 5+ Cited Publications SR-47436; BMS-186295	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan (SR-47436) is an orally active *Ang II type 1 (AT1) receptor* blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-D0845

Nitrosoglutathione 5+ Cited Publications GSNO; RVC-588; S-Nitroso-L-glutAThione	Endogenous Metabolite Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .

HY-B0205

Candesartan 5+ Cited Publications CV 11974	Angiotensin Receptor PPAR	Cardiovascular Disease Endocrinology Cancer
Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) .

HY-100113

Buloxibutid 5 Publications Verification AT2 receptor agonist C21	Angiotensin Receptor p38 MAPK TGF-beta/Smad TGF-β Receptor MMP	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a K_i value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .

HY-17005

Olmesartan medoxomil CS 866	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC₅₀ of 66.2 μM.

HY-12765

Losartan Carboxylic Acid E-3174; EXP-3174	Drug Metabolite Angiotensin Receptor	Cardiovascular Disease
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .

HY-14914

Azilsartan 5+ Cited Publications TAK-536	Angiotensin Receptor Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-125976

ML233	Apelin Receptor (APJ)	Cardiovascular Disease
ML233 is a non-peptide based potent *apelin receptor* (APJ) agonist (EC₅₀*=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor* (>79 μM) .

HY-B0780

Fimasartan 4 Publications Verification BR-A-657	Angiotensin Receptor Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Fimasartan (BRA-657) is an orally effective angiotensin receptor AT1 non-peptide antagonist. Fimasartan has antihypertensive effects. Fimasartan improves neuroinflammation and brain injury mediated by NLRP3 inflammatome after intracerebral hemorrhage, and has neuroprotective effect. Fimasartan inhibits the expression of inducible nitric oxide synthase through the inactivation of NF-κB and activator protein-1 .

HY-102093

ZD 7155hydrochloride 1 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 *receptor*) antagonist.

HY-17512AR

Losartan potassium (Standard) DuP-753 potassium (Standard)	Reference Standards Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan (potassium) (Standard) is the analytical standard of Losartan (potassium). This product is intended for research and analytical applications. Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-17512S

Losartan-d4 DuP-753 d₄	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-12765S

Losartan-d4 (carboxylic acid) E-3174 d₄; EXP-3174 d₄	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

HY-P3138

(Sar1)-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a K_d of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P3136

TRV055 TRV120055	Angiotensin Receptor ERK	Cardiovascular Disease
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-P1515A

Angiotensin II (3-8), human TFA 2 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT₁ receptor.

HY-W414915

Valsartan methyl ester CGP 48933 methyl ester	Drug Derivative Angiotensin Receptor	Cardiovascular Disease Cancer
Valsartan (CGP 48933) methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective and orally active angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure .

HY-B0202S1

Irbesartan-d6	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-131264

Olmesartan medoxomil impurity C Dehydro Olmesartan medoxomil	Drug Intermediate	Metabolic Disease
Olmesartan medoxomil impurity C (Dehydro Olmesartan medoxomil) is an uncharacterized impurity of Olmesartan medoxomil (HY-17005). Olmesartan medoxomil is a potent and selective angiotensin (angiotensin AT1) receptor inhibitor with an IC₅₀ of 66.2 μM .

HY-P3136A

TRV055 hydrochloride TRV120055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-112824

L-162313	Angiotensin Receptor	Cardiovascular Disease
L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC₅₀ values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth .

HY-13955S2

Telmisartan-13C,d3 BIBR 277-¹³C,d₃	Isotope-Labeled Compounds Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-B0202S

Irbesartan-d4 SR-47436-d₄; BMS-186295-d₄	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Irbesartan-d₄ (SR-47436-d₄) is the deuterium labeled Irbesartan Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

HY-19165

CI-996	Angiotensin Receptor	Cardiovascular Disease
CI-996 is a potent, selective, orally active angiotensin II (Ang II) type 1 (AT1) receptor antagonist. In rat liver membranes CI-996 displaces specifically bind [ ¹²⁵I]Ang II with an IC₅₀ of 0.8 nM. CI-996 has blood pressure-lowering activity .

HY-13955S

Telmisartan-d3	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S3

Telmisartan-d7 BIBR 277-d₇	Isotope-Labeled Compounds Autophagy Angiotensin Receptor	Cardiovascular Disease
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17512S3

Losartan-d2 DuP-753-d₂	Angiotensin Receptor	Others
Losartan-d₂ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17005R

Olmesartan medoxomil (Standard) CS 866 (Standard)	Reference Standards Angiotensin Receptor	Cardiovascular Disease Endocrinology
Olmesartan medoxomil (Standard) is the analytical standard of Olmesartan medoxomil. This product is intended for research and analytical applications. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC₅₀ of 66.2 μM.

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-101618

L162389	Angiotensin Receptor	Cardiovascular Disease
L162389 is a potent antagonist of angiotensin AT1 receptor with K_i of 28 nM.

HY-13955R

Telmisartan (Standard) BIBR 277 (Standard)	Reference Standards Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-A0229

Saprisartan GR 138950	Angiotensin Receptor	Others
Saprisartan (GR 138950) is a selective, long-acting AT1 receptor antagonist with low receptor dissociation kinetics.

HY-P1515

Angiotensin II (3-8), human	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT₁ receptor.

HY-105506

EXP-7711	Angiotensin Receptor	Cardiovascular Disease
EXP-7711 is a non peptide angiotensin II (Ang II) AT1 receptor antagonist. EXP-7711’s affinity for wild-type AT1 receptor (K_i =180 nM) is lower than peptide antagonists, but higher than losartan (K_i = 12 nM). EXP-7711 can be used for research on cardiovascular conditions .

HY-108120

L-162537	Angiotensin Receptor	Cardiovascular Disease
L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC₅₀=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension .

HY-19253A

KRH-594	Angiotensin Receptor	Cardiovascular Disease Metabolic Disease
KRH-594 is an orally active angiotensin AT1 receptor antagonist. KRH-594 ameliorates the progression of diabetic nephropathy and hyperlipidaemia. KRH-594 inhibits cardiac hypertrophy .

HY-105011A

YM-358 hydrate potassium	Angiotensin Receptor	Cardiovascular Disease
YM-358 hydrate potassium is an orally active angiotensin II type 1 (AT1)-receptor antagonist. YM-358 hydrate potassium can decrease cardiac volume overload. YM-358 hydrate potassium can be used for the research of cardiovascular disease, such as hypertension .

HY-A0224

Forasartan SC-52458	Angiotensin Receptor	Cardiovascular Disease
Forasartan is an nonpeptide angiotensin **AT₁ receptor antagonist with an IC₅₀** of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II .

HY-P11389

(Sar1,Gly8)-Angiotensin II	Angiotensin Receptor	Neurological Disease
(Sar1,Gly8)-Angiotensin II is an *AT1* angiotensin II receptor subtype selective antagonist (K_i: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II .

HY-B0202A

Irbesartan hydrochloride SR-47436 hydrochloride; BMS-186295 hydrochloride	Angiotensin Receptor Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease
Irbesartan (SR-47436) hydrochloride is an orally active *Ang II type 1 (AT1) receptor* blocker (ARB)**. Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0205R

Candesartan (Standard) CV 11974 (Standard)	Reference Standards Angiotensin Receptor PPAR	Cardiovascular Disease Endocrinology Cancer
Candesartan (Standard) is the analytical standard of Candesartan. This product is intended for research and analytical applications. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) .

HY-14914S1

Azilsartan-d4 TAK-536-d₄	Apoptosis Angiotensin Receptor Reactive Oxygen Species (ROS)	Cancer
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-B0205S

Candesartan-d4 CV-11974-d₄	Angiotensin Receptor	Others
Candesartan-d₄ (CV-11974-d₄) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

HY-121313

Embusartan BAY 10-6734	Angiotensin Receptor	Neurological Disease Endocrinology
Embusartan (BAY 10-6734) is a brain-penetrant and effective **AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors** in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension .

HY-114586

L-158809	Angiotensin Receptor	Cancer
L-158809 is an angiotensin type 1 (AT1) receptor antagonist that prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. L-158809 is promising for research of brain tumor .

HY-114284

L-163958	Angiotensin Receptor	Cardiovascular Disease
L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for *AT1* and AT2, with its IC₅₀ values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases .

Cat. No.	Product Name	Target	Research Area

HY-P3138

(Sar1)-Angiotensin II	Angiotensin Receptor	Cardiovascular Disease
(Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a K_d of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes .

HY-P1769

Angiotensin II (5-8), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P3136

TRV055 TRV120055	Angiotensin Receptor ERK	Cardiovascular Disease
TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-110183

Angiotensin A	Peptides	Cardiovascular Disease
Angiotensin A is a renin–angiotensin system (RAS) peptide that causes a vasoconstrictive effect dependent on AT₁ receptors. Angiotensin A elicits pressor and renal vasoconstrictor responses in normotensive and hypertensive rats .

HY-P3136A

TRV055 hydrochloride TRV120055 hydrochloride	Angiotensin Receptor	Cardiovascular Disease
TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses ^[1]

HY-P1792

Angiotensin II (1-4), human	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

HY-P1515

Angiotensin II (3-8), human	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT₁ receptor.

HY-P11389

(Sar1,Gly8)-Angiotensin II	Angiotensin Receptor	Neurological Disease
(Sar1,Gly8)-Angiotensin II is an *AT1* angiotensin II receptor subtype selective antagonist (K_i: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II .

HY-P1792A

Angiotensin II (1-4), human TFA	Angiotensin Receptor	Metabolic Disease Endocrinology
Angiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca ²⁺ levels. Angiotensin II also acts at the Na ⁺/H ⁺ exchanger in the proximal tubules of the kidney .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N14205

Cytosporin A	Natural Products Microorganisms Source Classification	Angiotensin Receptor
Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Cytosporin A has IC₅₀ values of 25-30 μM and 1.5-3 μM for *AT₁* and AT₂, respectively .

Cat. No.	Product Name	Chemical Structure

HY-17512S

Losartan-d4
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-12765S

Losartan-d4 (carboxylic acid)

Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

HY-B0202S1

Irbesartan-d6
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-B0202S

Irbesartan-d4

Irbesartan-d₄ (SR-47436-d₄) is the deuterium labeled Irbesartan Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17512S3

Losartan-d2
Losartan-d₂ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-B0205S

Candesartan-d4
Candesartan-d₄ (CV-11974-d₄) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-17512AS

Losartan-d6 hydrochloride
Losartan-d₆ hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-17512S1

Losartan-d3 Carboxylic Acid
Losartan-d₃ Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512S4

Losartan-d9
Losartan-d₉ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17005S

Olmesartan medoxomil-d6
Olmesartan medoxomil-d₆ (CS 866-d₆) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC₅₀ of 66.2 μM .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan . Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active *Ang II type 1 (AT1) receptor* blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

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