1. GPCR/G Protein
  2. Angiotensin Receptor

Angiotensin II (3-8), human 

Cat. No.: HY-P1515
Handling Instructions

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor. Sequence: Val-Tyr-Ile-His-Pro-Phe;VYIHPF.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II (3-8), human Chemical Structure

Angiotensin II (3-8), human Chemical Structure

CAS No. : 12676-15-2

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25 mg USD 310 Get quote

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Description

Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor. Sequence: Val-Tyr-Ile-His-Pro-Phe;VYIHPF.

IC50 & Target

Angiotensin AT1 receptor[1]

In Vivo

Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2905 mL 6.4524 mL 12.9047 mL
5 mM 0.2581 mL 1.2905 mL 2.5809 mL
10 mM 0.1290 mL 0.6452 mL 1.2905 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]
Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

774.91

Formula

C₄₀H₅₄N₈O₈

CAS No.

12676-15-2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Angiotensin II (3-8), human
Cat. No.:
HY-P1515
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Angiotensin II (3-8), human

Cat. No.: HY-P1515