A-81282
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats.
For research use only. We do not sell to patients.
- CAS No.: 141872-46-0
- Formula: C23H23N7O2
- Molecular Weight:429.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Angiotensin Receptor Isoforms
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Biological Activity
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AT1 Receptor 9.64 (pA2) |
Chemical Information
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CAS No. 141872-46-0
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Molecular Weight 429.47
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Formula C23H23N7O2
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SMILES
O=C(C1=CN=CN=C1N(CCCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
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Synonyms
Abbott 81282
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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