2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Fonsartan

Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI).

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Fonsartan

Fonsartan Chemical Structure

CAS No. : 153235-15-5

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Fonsartan Related Antibodies

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Description

Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI)[1][2].

IC50 & Target

AT1 Receptor

 

In Vitro

Fonsartan selectively inhibits AT1 receptors (mainly in the adrenal cortex (IC50 = 1.5 × 10-8 M)) while having a lower affinity for AT2 receptors (mainly in the adrenal medulla (IC50 = 1.4 × 10-6 M))[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fonsartan Related Antibodies
In Vivo

Fonsartan (3 mg/kg, s.c., once daily for 6 weeks) produces the most comprehensive cardioprotective effect when administered to rats with myocardial infarction (MI) modeling starting 3 to 24 hours after modeling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A myocardial infarction (MI) model was induced in male normotensive Wistar rats (weighing 250-280 g) by ligating the left anterior descending coronary artery[1].
Dosage: 3 mg/kg
Administration: S.c., once daily for 6 weeks
Result: Administration at 30 min, 3 h, 24 h, and 7 d post-administration all inhibited myocardial hypertrophy.
Administration at 3 h and 24 h post-administration significantly reduced infarct size.
Limited effect on improving left ventricular dilation (LVD, LVC).
Molecular Weight

620.87

Formula

C26H30K2N4O5S2
CAS No.
SMILES

O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(N([K])C(NCCC)=O)=O)C=CC=C3)C=C2)O[K]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fonsartan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fonsartan153235-15-5HR 720HR720HR-720Angiotensin ReceptorAT1 receptor antagonistRenin–angiotensin systemRASInhibitorinhibitorinhibit

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