Olmesartan medoxomil impurity C
Based on 1 Customer Validation
Olmesartan medoxomil impurity C (Dehydro Olmesartan medoxomil) is an uncharacterized impurity of Olmesartan medoxomil (HY-17005). Olmesartan medoxomil is a potent and selective angiotensin (angiotensin AT1) receptor inhibitor with an IC50 of 66.2 μM.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 879562-26-2
- Formula: C29H28N6O5
- Molecular Weight:540.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AT1 Receptor |
Olmesartan medoxomil impurity C (comes from the process from Claim 2 of the patent) can serve as an impurity reference standard: In the processes of drug research and development, production, and quality control (QC), Olmesartan medoxomil impurity C acts as a reference substance with known chemical structure, content and purity. By comparing it with drug samples, it assists in the identification and analysis of specific impurities in Olmesartan medoxomil (HY-17005) raw materials or preparations, and is used to evaluate the safety and efficacy of the drug[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 879562-26-2
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Appearance Solid
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Molecular Weight 540.57
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Formula C29H28N6O5
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Color White to off-white
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SMILES
O=C(C1=C(C(C)=C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2)OCC5=C(C)OC(O5)=O
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Synonyms
Dehydro Olmesartan medoxomil
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (184.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.8499 mL | 9.2495 mL | 18.4990 mL | 46.2475 mL |
| 5 mM | 0.3700 mL | 1.8499 mL | 3.6998 mL | 9.2495 mL | |
| 10 mM | 0.1850 mL | 0.9249 mL | 1.8499 mL | 4.6247 mL | |
| 15 mM | 0.1233 mL | 0.6166 mL | 1.2333 mL | 3.0832 mL | |
| 20 mM | 0.0925 mL | 0.4625 mL | 0.9249 mL | 2.3124 mL | |
| 25 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8499 mL | |
| 30 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5416 mL | |
| 40 mM | 0.0462 mL | 0.2312 mL | 0.4625 mL | 1.1562 mL | |
| 50 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9249 mL | |
| 60 mM | 0.0308 mL | 0.1542 mL | 0.3083 mL | 0.7708 mL | |
| 80 mM | 0.0231 mL | 0.1156 mL | 0.2312 mL | 0.5781 mL | |
| 100 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL |
Olmesartan medoxomil impurity C Related Classifications
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