2. GPCR/G Protein
  3. Angiotensin Receptor
  4. L-163958

L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases.

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L-163958

L-163958 Chemical Structure

CAS No. : 168473-51-6

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L-163958 Related Antibodies

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AT1 Receptor AT2 Receptor

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Description

L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases[1].

IC50 & Target[1]

AT1 Receptor

0.16 nM (IC50)

AT2 Receptor

0.12 nM (IC50)

Molecular Weight

730.64

Formula

C33H37BrFN5O6S
CAS No.
SMILES

O=C(OC(C)(C)C)NS(=O)(C1=CC=CC=C1C2=CC=C(CN3C(CC)=NN(C4=CC(NC(CCCC)=O)=CC=C4Br)C3=O)C(F)=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-163958 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-163958168473-51-6L163958L 163958Angiotensin Receptorangiotensin II receptor antagonistAT1AT2balanced inhibitortriazolinonehypertensionrenin-angiotensin systemoral activitystructure-activity relationshipInhibitorinhibitorinhibit

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