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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
NF-κB-MAPK
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "NF-κB-MAPK" in MCE Product Catalog:
6
Target:
Research Areas:
Carboxyamidotriazole (L-651582) is an orally active cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole inhibits NF-κB, MAPK activation and NO production. Carboxyamidotriazole has anti-angiogenic and anti-inflammatory activities. Carboxyamidotriazole has anticancer activity against liver cancer, lung cancer and leukemia .
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6 Cited Publications
Cat. No.: HY-N0430A
CAS No.: 1198398-71-8
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2
1
1 Cited Publications
Cat. No.: HY-171658
CAS No.: 3070346-91-4
Research Areas:
R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation .
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1 Cited Publications
Cat. No.: HY-N2491
CAS No.: 29307-03-7
Category:
Terpenoids Sesquiterpenes Amorpha fruticosaL. Plants Compositae Extract Disease Research Fields Cancer
Target:
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1
Category:
Cardiovascular Disease Neurological Disease Plants Solanaceae Extract Infection Alkaloids Capsicum annuum L. Other Alkaloids Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
1
1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Cat. No.: HY-B1104
CAS No.: 31842-01-0
Synonyms: (±)-Indoprofe
Research Areas:
Indoprofen ((±)-Indoprofe) activates AKT-AMPK signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active .
Category:
Cardiovascular Disease Chrysanthemum × morifolium (Ramat.) Hemsl. Umbelliferae Extract Coumarins Phenylpropanoids Plants Disease Research Fields
Target:
Potassium Channel PI3K NF-κB Akt p38 MAPK ERK COX NO Synthase JNK Apoptosis
Cat. No.: HY-46866
CAS No.: 34348-59-9
Target:
Research Areas:
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .
Cat. No.: HY-N0204
CAS No.: 129724-84-1
Synonyms: Anemoside A3
Cat. No.: HY-N1904
CAS No.: 57096-02-3
Synonyms: 8-Methoxyapigenin
Cat. No.: HY-168482
CAS No.: 3070509-60-0
NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
