Pulchinenoside A (Synonyms: Anemoside A3)

Cat. No.: HY-N0204 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice.

For research use only. We do not sell to patients.

Pulchinenoside A Chemical Structure

CAS No. : 129724-84-1

Size	Price	Stock	Quantity
Solution
10 mM * 1 mL in DMSO	USD 119	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 119	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 84	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 144	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Pulchinenoside A:

Pulchinenoside C In-stock

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Biological Activity
Purity & Documentation
References
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Description

Pulchinenoside A is a natural triterpenoid saponin that enhances synaptic plasticity in the adult mouse hippocampus and facilitates spatial memory in adult mice. In vitro: Additions of pulsatilloside A and anemoside A3, at dosages ranging from 0.1, 1 and 10 μg/ml, protected PC12 cells from apoptosis. [1] In vivo:AA3 also acts as a non-competitive NMDA receptor (NMDAR) modulator with a neuroprotective capacity against ischemic brain injury and overexcitation in rats. [2] Anemoside A3 produces relaxation in rat renal arteries through multiple mechanisms. [3]

IC₅₀ & Target

NMDA Receptor

Molecular Weight

750.96

Appearance

Solid

Formula

C₄₁H₆₆O₁₂

CAS No.

129724-84-1

SMILES

C[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@]([H])(O[C@@H]2[C@@H](O)[C@@H](O)CO[C@@]2([H])O[C@@H]3[C@](CO)(C)[C@]4([H])CC[C@@]5(C)[C@]6(C)CC[C@@]7(C(O)=O)CC[C@@H](C(C)=C)[C@]7([H])[C@@]6([H])CC[C@]5([H])[C@@]4(C)CC3)O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (66.58 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3316 mL	6.6581 mL	13.3163 mL
5 mM	0.2663 mL	1.3316 mL	2.6633 mL
10 mM	0.1332 mL	0.6658 mL	1.3316 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (3.33 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (3.33 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (3.33 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (258 KB) HNMR (302 KB)

Handling Instructions (2659 KB)

References

[1]. Ip FC et al. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015 Jul;40(8):1877-87. [Content Brief]

[2]. Zhang DM et al. Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Med. 2010 Nov;76(16):1814-9. [Content Brief]

[3]. Gao XD et al. Pulsatilloside A and anemoside A3 protect PC12 cells from apoptosis induced by sodium cyanide and glucose deprivation. Planta Med. 2003 Feb;69(2):171-4. [Content Brief]

Pulchinenoside A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Pulchinenoside A129724-84-1Anemoside A3Anemoside A 3Anemoside A-3iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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