1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Oxypeucedanin

Oxypeucedanin 

Cat. No.: HY-N0747
Handling Instructions

Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration.

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Oxypeucedanin Chemical Structure

Oxypeucedanin Chemical Structure

CAS No. : 737-52-0

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Description

Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

IC50 & Target

IC50: HKv1.5 current; apoptosis[1]

Molecular Weight

286.28

Formula

C₁₆H₁₄O₅

CAS No.

737-52-0

SMILES

CC1(C)C(O1)COC2=C(C=CO3)C3=CC(O4)=C2C=CC4=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OxypeucedaninPotassium ChannelKcsABlockercardiac action potential durationAPDatrial fibrillationantiarrhythmicInhibitorinhibitorinhibit

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