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  3. Deoxyelephantopin

Deoxyelephantopin 

Cat. No.: HY-N2491
Handling Instructions

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.

For research use only. We do not sell to patients.

Deoxyelephantopin Chemical Structure

Deoxyelephantopin Chemical Structure

CAS No. : 29307-03-7

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Description

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].

IC50 & Target

NF-κB

 

In Vitro

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1].
Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].

Molecular Weight

344.36

Formula

C₁₉H₂₀O₆

CAS No.

29307-03-7

SMILES

C=C(C)C(O[[email protected]@H](CC1=C2)[[email protected]]3([H])[[email protected]@](OC(C3=C)=O)([H])/C=C(C)/C[[email protected]@]2([H])OC1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DeoxyelephantopinNF-κBNuclear factor-κBNuclear factor-kappaBanticancerMAPKPI3KAktβ-cateninInhibitorinhibitorinhibit

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