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Results for "

TFR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Transferrin Receptor (16) ACSL Family (1) ADC Linker (1) Amyloid-β (1) Antibiotic (2) Antibody-Oligonucleotide Conjugates (AOCs) (1) Dystrophin (1) Ferroptosis (7) Glutathione Peroxidase (2) Liposome (8) PROTACs (1) Reactive Oxygen Species (ROS) (4) Reference Standards (1) Small Interfering RNA (siRNA) (5) VDAC (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (7)
Oligonucleotides:	Pegylated Lipids (7) Aptamers (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Transferrin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human *TFR1* .

HY-P991047

*Anti-CD71/TfR1 Antibody* JR-141 antibody (uncoupled from iduronate 2-sulfatase)	Transferrin Receptor	Neurological Disease Cancer
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-172723

DSPE-PEG2000-T7	Liposome Transferrin Receptor	Neurological Disease Cancer
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to *TfR*. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-P2297

TfR-T12	Transferrin Receptor	Metabolic Disease
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-159569

TfR-1-IN-1 1 Publications Verification	Transferrin Receptor Ferroptosis	Cancer
TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC₅₀ values of 0.51, 0.46, and 0.48 μM, respectively .

HY-P11099

Cys-LT7	Transferrin Receptor	Neurological Disease Cancer
Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .

HY-P990129

*Anti-Mouse CD71/TfR1 Antibody (8D3)*	Transferrin Receptor	Infection
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection .

HY-P2314

HAIYPRH hydrochloride	Transferrin Receptor	Cancer
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .

HY-P991381

*JST-TfR09* PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .

HY-N9362

Emodinanthrone EmodAN	Ferroptosis Antibiotic	Cardiovascular Disease Infection
Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC₅₀=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of *TFR1* via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .

HY-P990130

*Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)*	Transferrin Receptor	Neurological Disease
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat *CD71/TfR1. Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .

HY-P990856

Anti-CD71 Antibody (OKT-9)	Transferrin Receptor	Cancer
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .

HY-177564

Delpacibart zotadirsen Del-zota; AOC 1044	Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor Dystrophin	Neurological Disease
Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .

HY-P990791

*Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)*	Transferrin Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse *CD71/TfR1. Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3) can deplete CD71 ⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .

HY-RS21441

Tfr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tfr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tfr2 Mouse Pre-designed siRNA Set A Tfr2 Mouse Pre-designed siRNA Set A

HY-177454

Basivarsen linker	ADC Linker	Others
Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab (HY-P990780 Zeleciment) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

HY-RS14431

TFRC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFRC Human Pre-designed siRNA Set A TFRC Human Pre-designed siRNA Set A

HY-P2297A

TfR-T12 TFA	Transferrin Receptor	Metabolic Disease
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-RS14430

TFR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for TFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFR2 Human Pre-designed siRNA Set A TFR2 Human Pre-designed siRNA Set A

HY-172691

DSPE-PEG5000-THRPPMWSPVWP	Liposome	Cancer
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172690

DSPE-PEG2000-THRPPMWSPVWP	Liposome	Cancer
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-176212

Ferroptosis-IN-20	Ferroptosis VDAC Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC₅₀: 24.2 nM) targeting voltage-dependent anion channel (VDAC). Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe ²⁺ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637)-induced acute kidney injury (AKI) .

HY-RS16743

Tfrc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tfrc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfrc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tfrc Mouse Pre-designed siRNA Set A Tfrc Mouse Pre-designed siRNA Set A

HY-179384

PROTAC FSP1 degrader 1	ACSL Family PROTACs Ferroptosis Glutathione Peroxidase Transferrin Receptor Reactive Oxygen Species (ROS)	Cancer
PROTAC FSP1 degrader 1 is a highly efficient and selective PROTAC degrader targeting FSP1. PROTAC FSP1 degrader 1 significantly induces the accumulation of intracellular lipid peroxides. PROTAC FSP1 degrader 1 exhibits synergistic induction of ferroptosis with GPX4 inhibitors. PROTAC FSP1 degrader 1 can induce ROS production. PROTAC FSP1 degrader 1 upregulates the mRNA expression of ferroptosis-related proteins (GPX4, FTH1, ACSL4, *TfR1*, FSP1). PROTAC FSP1 degrader 1 can be used for the study of triple-negative breast cancer .

HY-172723A

DSPE-PEG3400-T7	Liposome	Cancer
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .

HY-172724

DSPE-PEG5000-T7	Liposome	Cancer
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .

HY-172722

DSPE-PEG1000-T7	Liposome	Cancer
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .

HY-177820

XQ-2d sodium	Transferrin Receptor	Cancer
XQ-2d sodium is an aptamer that targets TfR/CD71. XQ-2d binds to PL45 cells through recognizing CD71 protein.

HY-181953

*STIM1-TFR1-IN-1*	Transferrin Receptor Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase	Neurological Disease
STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 (STIM1)-transferrin receptor 1 (TFR1) protein complex inhibitor with a K_d of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis, lipid peroxidation and ROS production, enhances glutathione peroxidase 4 (GPX4) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage .

HY-N9362R

Emodinanthrone (Standard) EmodAN (Standard)	Reference Standards Antibiotic Ferroptosis	Infection
Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC₅₀=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of *TFR1* via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .

HY-RS27959

Tfr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tfr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tfr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tfr2 Rat Pre-designed siRNA Set A Tfr2 Rat Pre-designed siRNA Set A

HY-172690A

DSPE-PEG3400-THRPPMWSPVWP	Liposome	Cancer
DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172689

DSPE-PEG1000-THRPPMWSPVWP	Liposome	Cancer
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

Cat. No.	Product Name	Type

HY-172723

DSPE-PEG2000-T7	Biochemical Assay Reagents
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to *TfR*. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

DSPE-PEG2000-T7

Biochemical Assay Reagents

DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to TfR. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-172691

DSPE-PEG5000-THRPPMWSPVWP	Biochemical Assay Reagents
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172690

DSPE-PEG2000-THRPPMWSPVWP	Biochemical Assay Reagents
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172723A

DSPE-PEG3400-T7	Biochemical Assay Reagents
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .

HY-172724

DSPE-PEG5000-T7	Biochemical Assay Reagents
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .

HY-172722

DSPE-PEG1000-T7	Biochemical Assay Reagents
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .

HY-172690A

DSPE-PEG3400-THRPPMWSPVWP	Biochemical Assay Reagents
DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172689

DSPE-PEG1000-THRPPMWSPVWP	Biochemical Assay Reagents
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

Cat. No.	Product Name	Target	Research Area

HY-P2297

TfR-T12	Transferrin Receptor	Metabolic Disease
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

HY-P11099

Cys-LT7	Transferrin Receptor	Neurological Disease Cancer
Cys-LT7 is a transferrin receptor (TfR)-targeting peptide ligand. Cys-LT7 binds to a TfR site distinct from endogenous transferrin, mediates conjugated Doxorubicin (HY-15142A) delivery to TfR-overexpressed tumor cells, and exhibits low toxicity to TfR-low-expressed normal cells. Cys-LT7 is an L-configuration peptide susceptible to proteolytic enzymes, leading to poor biostability in peptide-drug conjugates. Cys-LT7 can be used for the research of glioblastoma, hepatocellular carcinoma, lung carcinoma .

HY-P2314

HAIYPRH hydrochloride	Transferrin Receptor	Cancer
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrin receptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .

HY-P2297A

TfR-T12 TFA	Transferrin Receptor	Metabolic Disease
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9999

Trontinemab RG6102; RO-7126209	Amyloid-β	Neurological Disease
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human *TFR1* .

HY-P991047

*Anti-CD71/TfR1 Antibody* JR-141 antibody (uncoupled from iduronate 2-sulfatase)	Transferrin Receptor	Neurological Disease Cancer
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71/TfR1) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990129

*Anti-Mouse CD71/TfR1 Antibody (8D3)*	Transferrin Receptor	Infection
Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived anti-mouse CD71/TfR1 IgG2a type antibody inhibitor. Anti-Mouse CD71/TfR1 Antibody (8D3) depletes of CD71+ erythroid cells but does not change percentages of Tregs in neonatal mice. Anti-Mouse CD71/TfR1 Antibody (8D3) enhances neonatal mice defence against infection .

HY-P991381

*JST-TfR09* PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) .

HY-P990130

*Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26)*	Transferrin Receptor	Neurological Disease
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat *CD71/TfR1. Anti-Mouse/Rat CD71/TfR1* Antibody (OX-26) targets the transferrin receptor and binds to an extracellular domain for the transferrin receptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .

HY-P990856

Anti-CD71 Antibody (OKT-9)	Transferrin Receptor	Cancer
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrin receptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .

HY-P990791

*Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)*	Transferrin Receptor	Infection Inflammation/Immunology Cancer
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse *CD71/TfR1. Anti-Mouse CD71/TfR1* Antibody (R17 217.1.3) can deplete CD71 ⁺ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9362

Emodinanthrone EmodAN	Infection Structural Classification Classification of Application Fields Phenols Polyphenols Plants Rhamnaceae Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang Disease Research Fields Source Classification	Ferroptosis Antibiotic
Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC₅₀=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of *TFR1* via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .

HY-N9362R

Emodinanthrone (Standard) EmodAN (Standard)	Structural Classification Phenols Polyphenols Plants Rhamnaceae Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang Source Classification	Reference Standards Antibiotic Ferroptosis
Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC₅₀=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of *TFR1* via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .

Species:	Human (7) Rhesus Macaque (1) Mouse (7) Rat (2) Cynomolgus (4) Pig (2)
Tag:	His (15) Tag Free (1) Avi (6) Fc (6)
Source:	HEK293 (22)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77855

	TFRC Protein, Cynomolgus (HEK293, His) TR; TFR1; CD71; sTFR; T9; p90; TFRC; TFR	Cynomolgus	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release. TFRC actively regulates T and B cell proliferation through iron uptake. TFRC Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag.

HY-P705204

	TFRC Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) CD71; TFRC; TFR; sTFR; TFR1; Trfr; T9; p90	Cynomolgus	HEK293

HY-P705163

	TFRC Protein, Rat (Biotinylated, HEK293, His-Avi) Transferrin receptor protein 1; TFRc; TR; TFR; TFR1; Trfr; CD71	Rat	HEK293

HY-P78523

	TFRC Protein, Human (HEK293, His-Avi) TR; TFR1; CD71; sTFR; T9; p90; TFRC; TFR	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, His-Avi) is the recombinant human-derived TFRC protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P705097

	TFRC Protein, Human (Biotinylated, HEK293, Fc-Avi) TR; TFR1; CD71; sTFR; T9; p90; TFRC; TFR	Human	HEK293

HY-P705277

	TFRC Protein, Mouse (Biotinylated, HEK293, His-Avi) CD71; TFRC; TFR; sTFR; TFR1; Trfr; T9; p90	Mouse	HEK293

HY-P78904

	TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) CD71; TFRC; TFR; sTFR; TFR1; Trfr; T9; p90	Cynomolgus	HEK293
	TFRC proteins mediate iron uptake by triggering receptor-mediated endocytosis of ligand-occupied transferrin receptors, followed by acidification and iron release. It is essential for red blood cell and nervous system development, and for maintaining iron balance. TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag.

HY-P700841

	TFRC Protein, Human (Biotinylated, HEK293, His-Avi) TR; TFR1; CD71; sTFR; T9; p90; TFRC; TFR	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-Avi, N-His labeled tag.

HY-P701303

	TFRC Protein, Mouse (Biotinylated, HEK293, His) CD71; TFRC; TFR; sTFR; TFR1; Trfr; T9; p90	Mouse	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with His labeled tag.

HY-P704917

	TFRC Protein, Mouse (HEK293, Fc) Transferrin receptor protein 1; TR; TFR; TFR1; Trfr; CD71; TFRc	Mouse	HEK293

HY-P72455

	TFRC Protein, Mouse (HEK293, His) Transferrin receptor protein 1; TR; TFR; TFR1; Trfr; CD71; TFRc	Mouse	HEK293
	TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P704915

	TFRC Protein, Human (HEK293) Transferrin receptor protein 1; TR; TFR; Trfr; T9; p90	Human	HEK293

HY-P71069

	TFRC Protein, Human (HEK293, His) 2 Publications Verification Transferrin receptor protein 1; TR; TFR; Trfr; T9; p90	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, His) is the recombinant human-derived TFRC protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P704916

	TFRC Protein, Human (672a.a, HEK293, His) Transferrin receptor protein 1; TR; TFR; Trfr; T9; p90	Human	HEK293

HY-P74526

	TFRC Protein, Human (HEK293, hFc) Transferrin receptor protein 1; TR; TFR; Trfr; T9; p90	Human	HEK293
	TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, hFc) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P703859

	TFR1/CD71 Protein, Cynomolgus, (HEK293, His) transferrin receptor; TFRC	Cynomolgus;Rhesus Macaque	HEK293

HY-P78783

	Transferrin R2 Protein, Mouse (HEK293, mFc) Transferrin R2; TFR2	Mouse	HEK293
	The transferrin R2 protein is a key player in iron-independent cellular uptake of transferrin-bound iron, underscoring its role in delicate iron metabolism. Among other things, it may have crucial effects on liver cell function and red blood cell differentiation. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P73453

	Transferrin Protein, Mouse (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73454

	Transferrin Protein, Rat (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Rat	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its primary function is to transport iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Rat (HEK293, His) is the recombinant rat-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag.

HY-P73581

	Transferrin Protein, Mouse (HEK293, Fc) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Mouse	HEK293
	Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate.Its main function is to transport iron from the site of absorption to the site of storage and utilization.Transferrin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74494

	Transferrin Protein, Pig (HEK293, His) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, His) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag.

HY-P74495

	Transferrin Protein, Pig (HEK293, hFc) Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; TRF	Pig	HEK293
	Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, hFc) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag.

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Source
Tag
Accession
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Purity
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Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (2)
Application:	IHC-P (3) ICC/IF (1) IP (2) WB (3) FC (1) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3) Biotin (7)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86512

	Transferrin Receptor Antibody (YA6204) Transferrin receptor protein 1; TR; TFR; TFR1; Trfr; T9; p90; CD antigen CD71; [Cleaved into: Transferrin receptor protein 1, serum form; sTFR; ]	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Transferrin Receptor Antibody (YA6204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin Receptor.

HY-P81000

	Transferrin Receptor Antibody (YA3546) CD71 antibody; IMD46 antibody; OTTHUMP00000208523 antibody; p90 antibody; sTFR antibody; T9 antibody; TFR 1 antibody; TFR antibody; TFRC antibody; TR antibody; Transferrin receptor (p90 CD71) antibody	WB, IHC-P, IP, FC	Human, Mouse, Rat
	Transferrin Receptor Antibody (YA3546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin Receptor.

HY-P82100

	Transferrin Receptor 2 Antibody (YA1845) HFE3; TFR2; TFRC2	WB, IHC-P	Human
	Transferrin Receptor 2 Antibody (YA1845) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transferrin Receptor 2.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-172723

DSPE-PEG2000-T7		Pegylated Lipids
DSPE-PEG2000-T7 is a PEGylated compound composed of DSPE and peptideT7. T7 (HAIYPRH) specifically binds to *TfR*. DSPE-PEG2000-T7 can be used to prepare T7-modified liposomes, where liposomes modified with both T7 and DA7R peptides can effectively co-deliver Doxorubicin (HY-15142A) and Vincristine (HY-N0488A) to gliomas. DSPE-PEG2000-T7 can also be used to prepare nanomodulators that mediate the co-delivery of tyrosine hydroxylase mRNA and interferon gene stimulator antagonists for synergistic intervention in Parkinson's disease .

HY-RS21441

Tfr2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tfr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14431

TFRC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14430

TFR2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for TFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172691

DSPE-PEG5000-THRPPMWSPVWP		Pegylated Lipids
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-172690

DSPE-PEG2000-THRPPMWSPVWP		Pegylated Lipids
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

HY-RS16743

Tfrc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tfrc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tfrc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172723A

DSPE-PEG3400-T7		Pegylated Lipids
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG3400-T7 can be used for drug delivery .

HY-172724

DSPE-PEG5000-T7		Pegylated Lipids
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG5000-T7 can be used for drug delivery .

HY-172722

DSPE-PEG1000-T7		Pegylated Lipids
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrin receptor). DSPE-PEG1000-T7 can be used for drug delivery .

HY-177820

XQ-2d sodium		Aptamers
XQ-2d sodium is an aptamer that targets TfR/CD71. XQ-2d binds to PL45 cells through recognizing CD71 protein.

HY-RS27959

Tfr2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tfr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tfr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172689

DSPE-PEG1000-THRPPMWSPVWP		Pegylated Lipids
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrin receptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .

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