TFRC Protein, Human (Biotinylated, HEK293, His-Avi)

TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of TFRC Protein, Human (Biotinylated, HEK293, His-Avi) is 672 a.a., with molecular weight of 80-85 kDa.

TFRC protein facilitates cellular iron uptake through receptor-mediated endocytosis of ligand-occupied transferrin receptors into specialized endosomes, as documented in studies. This process involves endosomal acidification, leading to iron release, followed by recycling of the apotransferrin-receptor complex to the cell surface, accompanied by a return to neutral pH and the subsequent loss of apotransferrin affinity for its receptor. Crucial for erythrocyte and nervous system development, TFRC is a vital player in iron homeostasis. The hereditary hemochromatosis protein HFE competes with transferrin for binding at an overlapping C-terminal site. TFRC positively regulates T and B cell proliferation through iron uptake and acts as a lipid sensor, modulating mitochondrial fusion by regulating the JNK pathway. Depending on dietary stearate levels, TFRC either promotes JNK pathway activation and degradation of the mitofusin MFN2 when stearate is low or inhibits JNK pathway activation and MFN2 degradation when stearate is high. Furthermore, TFRC acts as a receptor for new-world arenaviruses, including Guanarito, Junin, and Machupo virus, during microbial infection.

Human

HEK293

N-His;N-Avi

P02786 (C89-F760)

7037  [NCBI]

80-85 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.