Transferrin R2 Protein, Mouse (HEK293, mFc)
Based on 1 Customer Validation
The transferrin R2 protein is a key player in iron-independent cellular uptake of transferrin-bound iron, underscoring its role in delicate iron metabolism. Among other things, it may have crucial effects on liver cell function and red blood cell differentiation. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293 , with N-mFc labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The transferrin R2 protein is a key player in iron-independent cellular uptake of transferrin-bound iron, underscoring its role in delicate iron metabolism. Among other things, it may have crucial effects on liver cell function and red blood cell differentiation. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293 , with N-mFc labeled tag.
Transferrin R2 Protein emerges as a key player in the cellular uptake of transferrin-bound iron, showcasing its role in iron metabolism. Intriguingly, this process occurs in a non-iron dependent manner, suggesting a nuanced and regulated mechanism of iron acquisition. Beyond its involvement in iron metabolism, Transferrin R2 may play crucial roles in hepatocyte function and erythrocyte differentiation, underscoring its significance in various cellular processes. The specific molecular mechanisms through which Transferrin R2 contributes to these functions remain to be fully elucidated, prompting further investigation into its functional significance and regulatory impact on iron-related pathways, hepatocytes, and erythrocyte development. Comprehensive studies are essential to unravel the precise molecular pathways through which Transferrin R2 exerts its effects and to understand its broader implications in cellular and physiological processes.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag N-mFc
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Accession
Q9JKX3-1 (R103-F798)
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Molecular Construction
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N-term
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mFc
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TFR2 (R103-F798)
Accession # Q9JKX3-1 -
C-term
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Protein Length
Extracellular Domain
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Synonyms
TFR2; Transferrin Receptor Protein 2; Transferrin Receptor 2; TFR2 Protein; TFRC2; TfR2; HFE3
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AA Sequence
RGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRERVAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQLPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFAQKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDLRLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLGDGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSAYSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQLLIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEKLRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALVDHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
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Predicted Molecular Mass
104.6 kDa
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Molecular Weight
Approximately 116 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (239 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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