Transferrin R2 Protein, Mouse (HEK293, mFc)

Transferrin R2 Protein is a key player in non-iron dependent cellular uptake of transferrin-bound iron, emphasizing its role in nuanced iron metabolism. Beyond this, it may crucially impact hepatocyte function and erythrocyte differentiation. The specific molecular mechanisms and regulatory impact on iron-related pathways remain to be fully elucidated, necessitating comprehensive studies to understand Transferrin R2's broader implications in cellular and physiological processes. Transferrin R2 Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived Transferrin R2 protein, expressed by HEK293, with N-mFc labeled tag. The total length of Transferrin R2 Protein, Mouse (HEK293, mFc) is 696 a.a., with molecular weight of ~116 kDa.

Transferrin R2 Protein emerges as a key player in the cellular uptake of transferrin-bound iron, showcasing its role in iron metabolism. Intriguingly, this process occurs in a non-iron dependent manner, suggesting a nuanced and regulated mechanism of iron acquisition. Beyond its involvement in iron metabolism, Transferrin R2 may play crucial roles in hepatocyte function and erythrocyte differentiation, underscoring its significance in various cellular processes. The specific molecular mechanisms through which Transferrin R2 contributes to these functions remain to be fully elucidated, prompting further investigation into its functional significance and regulatory impact on iron-related pathways, hepatocytes, and erythrocyte development. Comprehensive studies are essential to unravel the precise molecular pathways through which Transferrin R2 exerts its effects and to understand its broader implications in cellular and physiological processes.

Mouse

HEK293

N-mFc

Q9JKX3 (R103-F798)

50765  [NCBI]

RGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRERVAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQLPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFAQKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDLRLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVRTFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLGDGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSAYSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQLLIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEKLRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALVDHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF

Approximately 116 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.