Tfr2 - transferrin receptor 2 Gene

Also Known as Trfr2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50765

Summary

Predicted to enable co-receptor binding activity and Transferrin Receptor activity. Acts upstream of or within iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (Transferrin Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tfr2 Products (5)

mRNA Protein Name
NM_001289507.2 NP_001276436.2 transferrin receptor protein 2
NM_001289509.1 NP_001276438.1 transferrin receptor protein 2
NM_001289511.1 NP_001276440.1 transferrin receptor protein 2
NM_001359206.1 NP_001346135.1 transferrin receptor protein 2
NM_015799.4 NP_056614.3 transferrin receptor protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16893896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
22960056 MGI
Cellular Component GO Annotation Evidence References Source
part of HFE-transferrin receptor complex IDA
IDA: Inferred from direct assay
16893896 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transferrin receptor protein 2

Recombinant Tfr2 Proteins

Cat. No. Product Name Accession Purity
HY-P78783 Transferrin R2 Protein, Mouse (HEK293, mFc) Q9JKX3-1 (R103-F798) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21441 Tfr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14430 TFR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27959 Tfr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfr2 NCBI NCBI:7036