STIM1-TFR1-IN-1 

STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 (STIM1)-transferrin receptor 1 (TFR1) protein complex inhibitor with a K_d of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis, lipid peroxidation and ROS production, enhances glutathione peroxidase 4 (GPX4) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective
effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage^[1].

STIM1-TFR1-IN-1 (Compound S-IN-1) (0.15625-5 μM) directly and specifically binds to the STIM1-CD protein with a K_d of 2.18 μM^[1].
S-IN-1 (10-20 μM) inhibits the interaction between STIM1 and TFR1 in HT22 mouse neuronal cells exposed to Hemin (HY-19424) to model ICH^[1].
S-IN-1 (0-40 μM) attenuates neuronal ferroptosis and increases the vitality of neuronal cells in Hemin-treated HT22 mouse neuronal cells by reducing iron accumulation, lipid peroxidation, and ROS, while enhancing antioxidant defense system^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STIM1-TFR1-IN-1 (Compound S-IN-1) (10 mg/kg; p.o.; once every 24 h) significantly reduces brain tissue damage and continuously improves sensory, motor, and cognitive neurological deficits in a mouse model of intracerebral hemorrhage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

319.43

C₁₅H₂₁N₅OS

2196106-61-1

O=C(NC1=NN=C(C2CCC2)N1)[C@@H](N3C=CC=C3)CCSC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang H, et al. The Ca²⁺ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage. Cell Rep Med. 2026;7(2):102595.  [Content Brief]