TFRC Protein, Cynomolgus (Biotinylated, HEK293, His)

TFRC proteins mediate iron uptake by triggering receptor-mediated endocytosis of ligand-occupied transferrin receptors, followed by acidification and iron release. It is essential for red blood cell and nervous system development, and for maintaining iron balance. TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag. The total length of TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is 672 a.a., with molecular weight of 70-90 kDa.

TFRC protein orchestrates the cellular uptake of iron through receptor-mediated endocytosis of ligand-occupied transferrin receptors into specialized endosomes. This process involves endosomal acidification, leading to the release of iron, followed by the recycling of the apotransferrin-receptor complex to the cell surface with a return to neutral pH, concomitant with the loss of apotransferrin affinity for its receptor. Essential for the development of erythrocytes and the nervous system, TFRC serves a critical role in iron homeostasis. Beyond its iron-related functions, TFRC acts as a lipid sensor, regulating mitochondrial fusion by modulating the activation of the JNK pathway. Furthermore, TFRC forms homodimers through disulfide linkages, adding another layer to its multifaceted involvement in cellular processes.

Cynomolgus

HEK293

N-His

G8F602 (C89-F760)

/

70-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.