2. Apoptosis Anti-infection Membrane Transporter/Ion Channel
  3. TNF Receptor HIV SGLT
  4. Trilobatin

Trilobatin  (Synonyms: トリロバチン)

製品番号: HY-N4100 純度: 98.90%
COA 取扱説明書 Technical Support

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 4192-90-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 143 在庫あり
Solution
10 mM * 1 mL in DMSO USD 143 在庫あり
Solid
1 mg $60 在庫あり
5 mg $130 在庫あり
10 mg $185 在庫あり
25 mg $350 在庫あり
50 mg $520 在庫あり
100 mg $750 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Other Forms of Trilobatin:

Trilobatin 関連抗体

Top Publications Citing Use of Products

    Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926.  [Abstract]

    Representative images of hematoxylin-eosin (HE)-stained colon tissue sections treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

    Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926.  [Abstract]

    Expression levels of three inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the sera of mice measured by ELISA treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

    Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926.  [Abstract]

    Expression of mRNA levels of genes encoding tight junction proteins (ZO-1 and occludin) in colon tissue measured by qRT-PCR treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

    Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926.  [Abstract]

    Protein levels of tight junction proteins (ZO-1 and occludin) in colon tissue measured by western blotting analysis treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

    Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926.  [Abstract]

    Representative images of colon and colon length treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

    TNF Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    HIV アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    HIV HIV-1 HIV-2

    SGLT アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    SGLT1 SGLT2

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope[2]. Neuroprotective effects[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells[3].

    IC50 & Target[2][3]

    HIV-1

     

    SGLT1

     

    SGLT2

     

    体外実験

    Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Trilobatin 関連抗体
    分子量

    436.41

    分子式

    C21H24O10
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C=C1)=CC=C1CCC(C2=C(C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2O)O)=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (229.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2914 mL 11.4571 mL 22.9142 mL
    5 mM 0.4583 mL 2.2914 mL 4.5828 mL
    10 mM 0.2291 mL 1.1457 mL 2.2914 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 25 mg/mL (57.29 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 98.90%

    COA (248 KB) HNMR (267 KB) LCMS (99 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2914 mL 11.4571 mL 22.9142 mL 57.2856 mL
    5 mM 0.4583 mL 2.2914 mL 4.5828 mL 11.4571 mL
    10 mM 0.2291 mL 1.1457 mL 2.2914 mL 5.7286 mL
    15 mM 0.1528 mL 0.7638 mL 1.5276 mL 3.8190 mL
    20 mM 0.1146 mL 0.5729 mL 1.1457 mL 2.8643 mL
    25 mM 0.0917 mL 0.4583 mL 0.9166 mL 2.2914 mL
    30 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9095 mL
    40 mM 0.0573 mL 0.2864 mL 0.5729 mL 1.4321 mL
    50 mM 0.0458 mL 0.2291 mL 0.4583 mL 1.1457 mL
    60 mM 0.0382 mL 0.1910 mL 0.3819 mL 0.9548 mL
    80 mM 0.0286 mL 0.1432 mL 0.2864 mL 0.7161 mL
    100 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.5729 mL
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Trilobatin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trilobatin4192-90-9TNF ReceptorHIVSGLTTumor Necrosis Factor ReceptorTNFRHuman immunodeficiency virusSodium-dependent glucose cotransportersPC12AMPKNrf2Sirt3gp41envelopeentryAnti-tumorInhibitorinhibitorinhibit

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    製品名:
    Trilobatin
    製品番号:
    HY-N4100
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