2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants MMP Endogenous Metabolite
  4. Triolein

トリオレイン  (Synonyms: Triolein)

製品番号: HY-N1981 純度: 99.00%
COA 取扱説明書 Technical Support

Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 122-32-7

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Liquid
100 mg $30 在庫あり
500 mg $80 在庫あり
1 g $130 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Triolein:

トリオレイン 関連抗体

Top Publications Citing Use of Products
RT-PCR
IF
WB
In Vivo Efficacy Study
Histological Imaging/Staining

    Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242.  [Abstract]

    The expression of inflammatory cytokines IL-4, IL-10, TNF-α, IL-1β, IL-6, and IL-18 mRNAs in the ischemic penumbra treated with Triolein (40 mg/kg, p.o.).

    Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242.  [Abstract]

    The effect of Triolein on activation of proinflammatory microglia after ischemic stroke. Iba1, red, a surface marker of microglia; CD86, green, the surface marker of M1 microglia; DAPI, blue, Nuclei treated with Triolein (40 mg/kg, p.o.).

    Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242.  [Abstract]

    Western blot to detect the effect of Triolein (40 mg/kg, p.o.) on LC3-II/I and P62 protein expression in the C57BL/6J ipsilateral cortex after ischemic stroke brain injury.

    Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242.  [Abstract]

    Representative TTC staining assay was performed to evaluate the infarct volume treated with Triolein (10, 20, 40, 80 mg/kg, p.o.).

    Triolein purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Dec 6;30(1):242.  [Abstract]

    Nissl staining showing morphological neuronal changes in the ischemic penumbra 3 days after reperfusion treated with Triolein (10, 20, 40, 80 mg/kg, p.o.).

    MMP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Triolein (20 μM, 48 h) decreases the upregulation of MMP-1 in dermal fibroblasts produced by ROS[1].
    Triolein (10 μM, 24 h) can improve the oxidative stress induced by oxidative low-density lipoprotein in endothelial cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    トリオレイン 関連抗体

    RT-PCR[1]

    Cell Line: Tel‐E6E7
    Concentration: 20 μM
    Incubation Time: 48 h
    Result: Reduced the IL-6 expression and ROS generation.
    臨床実験
    分子量

    885.43

    分子式

    C57H104O6
    CAS 番号
    Appearance

    Liquid (Density: 0.91 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    O=C(CCCCCCC/C=C\CCCCCCCC)OC(COC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (112.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1294 mL 5.6470 mL 11.2939 mL
    5 mM 0.2259 mL 1.1294 mL 2.2588 mL
    10 mM 0.1129 mL 0.5647 mL 1.1294 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (2.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (2.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.00%

    COA (238 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1294 mL 5.6470 mL 11.2939 mL 28.2349 mL
    5 mM 0.2259 mL 1.1294 mL 2.2588 mL 5.6470 mL
    10 mM 0.1129 mL 0.5647 mL 1.1294 mL 2.8235 mL
    15 mM 0.0753 mL 0.3765 mL 0.7529 mL 1.8823 mL
    20 mM 0.0565 mL 0.2823 mL 0.5647 mL 1.4117 mL
    25 mM 0.0452 mL 0.2259 mL 0.4518 mL 1.1294 mL
    30 mM 0.0376 mL 0.1882 mL 0.3765 mL 0.9412 mL
    40 mM 0.0282 mL 0.1412 mL 0.2823 mL 0.7059 mL
    50 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.5647 mL
    60 mM 0.0188 mL 0.0941 mL 0.1882 mL 0.4706 mL
    80 mM 0.0141 mL 0.0706 mL 0.1412 mL 0.3529 mL
    100 mM 0.0113 mL 0.0565 mL 0.1129 mL 0.2823 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Triolein Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Triolein122-32-7Environmental PollutantsMMPEndogenous MetaboliteEnvironmental ContaminantsMatrix metalloproteinasesAnti-inflammatoryAntioxidantTel‐E6E7Endothelial cellsInhibitorinhibitorinhibit

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    製品名:
    Triolein
    製品番号:
    HY-N1981
    数量:
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