2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Autophagy
  3. CFTR Endogenous Metabolite Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase Autophagy
  4. Glucosamine

Glucosamine  (Synonyms: D-Glucosamine; Chitosamine)

Cat. No.: HY-B1125 Pureté: 98.0%
COA
SDS
Instruction de manipulation Technical Support

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

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CAS No. : 3416-24-8

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
500 mg En stock
1 g En stock
5 g   Obtenir un devis  
10 g   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Based on 11 publication(s) in Google Scholar

Other Forms of Glucosamine:

Glucosamine Related Antibodies

Top Publications Citing Use of Products

    Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). Cell death was measured after treatment for 24 h.

    Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). MDA was measured after treatment for 16 h.

    Glucosamine purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674.  [Abstract]

    Metabolites downstream of GFPT1 restore YAP alteration by erastin. p-YAPS127, O-YAPT241 and YAP were measured by IB in H1975 cells treated with or without erastin, glucose, GlcN (5 mM) or GlcNAc for 8 h.

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    • Activité biologique

    • Pureté et documentation

    • Références

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    Description

    Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    In Vitro

    Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity[2].
    Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
    Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Glucosamine Related Antibodies
    Essai clinique
    Masse moléculaire

    179.17

    Formule

    C6H13NO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O
    Structure Classification
    Initial Source
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvant et solubilité
    In Vitro: 

    H2O : 100 mg/mL (558.12 mM; ultrasonic and warming and heat to 60°C)

    DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.5812 mL 27.9061 mL 55.8123 mL
    5 mM 1.1162 mL 5.5812 mL 11.1625 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (279.06 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    Purity: 98.0%

    SDS (396 KB)

    COA (248 KB) HNMR (260 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 5.5812 mL 27.9061 mL 55.8123 mL 139.5307 mL
    5 mM 1.1162 mL 5.5812 mL 11.1625 mL 27.9061 mL
    10 mM 0.5581 mL 2.7906 mL 5.5812 mL 13.9531 mL
    15 mM 0.3721 mL 1.8604 mL 3.7208 mL 9.3020 mL
    H2O 20 mM 0.2791 mL 1.3953 mL 2.7906 mL 6.9765 mL
    25 mM 0.2232 mL 1.1162 mL 2.2325 mL 5.5812 mL
    30 mM 0.1860 mL 0.9302 mL 1.8604 mL 4.6510 mL
    40 mM 0.1395 mL 0.6977 mL 1.3953 mL 3.4883 mL
    50 mM 0.1116 mL 0.5581 mL 1.1162 mL 2.7906 mL
    60 mM 0.0930 mL 0.4651 mL 0.9302 mL 2.3255 mL
    80 mM 0.0698 mL 0.3488 mL 0.6977 mL 1.7441 mL
    100 mM 0.0558 mL 0.2791 mL 0.5581 mL 1.3953 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Glucosamine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Glucosamine3416-24-8D-Glucosamine ChitosamineCFTREndogenous MetaboliteReactive Oxygen Species (ROS)HIF/HIF Prolyl-HydroxylaseAutophagyCystic fibrosis transmembrane conductance regulatorHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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