2. Anti-infection Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway
  3. HSV MMP ERK p38 MAPK JNK
  4. Gallic aldehyde

Gallic aldehyde (3,4,5-Trihydroxybenzaldehyde) is a phenolic aldehyde. Gallic aldehyde can be isolated from Geum japonicum. Gallic aldehyde inhibits the gelatinolytic activity and expression of MMP-9. Gallic aldehyde also inhibits ERK1/2, p38, and JNK. Gallic aldehyde has potent anti-HSV-1 and antioxidant activities. Gallic aldehyde also exhibits antibacterial activity against Oenococcus oeni VF.

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Gallic aldehyde

Gallic aldehyde 화학구조

CAS No. : 13677-79-7

사이즈 가격 재고 수량
100 mg 해외재고보유
250 mg 해외재고보유
500 mg 해외재고보유
1 g 해외재고보유
5 g 해외재고보유
10 g   견적 받기  
50 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Gallic aldehyde:

Gallic aldehyde Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Gallic aldehyde

View All HSV Isoform Specific Products:

View All Isoforms
HSV-1 HSV-2 HSV

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

View All JNK Isoform Specific Products:

View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Gallic aldehyde (3,4,5-Trihydroxybenzaldehyde) is a phenolic aldehyde. Gallic aldehyde can be isolated from Geum japonicum. Gallic aldehyde inhibits the gelatinolytic activity and expression of MMP-9. Gallic aldehyde also inhibits ERK1/2, p38, and JNK. Gallic aldehyde has potent anti-HSV-1 and antioxidant activities. Gallic aldehyde also exhibits antibacterial activity against Oenococcus oeni VF[1][2][3][4].

IC50 & Target[1][2][3][4]

ERK1

 

ERK2

 

MMP-9

 

Cellular Effect
Cell Line Type Value Description References
A549 GI50
7.3 μM
Compound: 4
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HBL-100 GI50
72 μM
Compound: 4
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HBL100 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
HeLa GI50
16 μM
Compound: 4
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
SW1573 GI50
38 μM
Compound: 4
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human SW1573 cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
T47D GI50
43 μM
Compound: 4
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
WiDr GI50
39 μM
Compound: 4
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human WiDr cells after 48 hrs by sulforhodamine B assay
[PMID: 25752525]
In Vitro

Gallic aldehyde (12.5-50.0 μg/mL) shows potent antiviral activity against HSV-1 with no cytotoxicity in Vero cells[1].
Gallic aldehyde exhibits antioxidant activity, scavenging DPPH free radicals (SC50 = 19.5 mg/mL)[2].
Gallic aldehyde (20-500 mg/mL; 2-24 h) inhibits MMP-9 production as well as gelatinolytic activity in TNF-α-induced HASMC cultures[3].
Gallic aldehyde (250-500 mg/L) inhibits the growth of Oenococcus oeni VF in MRS/TJ medium (pH 4.5, 5% ethanol)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gallic aldehyde Related Antibodies

Cell Cytotoxicity Assay[3]

Cell Line: Human Aortic Smooth Muscle Cells (HASMCs)
Concentration: 10 μg/mL, 50 μg/mL, 200 μg/mL, 500 μg/mL
Incubation Time: 24 h
Result: Showed no significant cytotoxicity at concentrations up to 200 μg/mL, and the cell growth ratio was 65.6% at 500 μg/mL.

Western Blot Analysis[3]

Cell Line: Human Aortic Smooth Muscle Cells (HASMCs)
Concentration: 20 μg/mL, 50 μg/mL ;100 μg/mL
Incubation Time: 30 s; 5 min; 15 min; 30 min; 2 h; 4 h; 6 h; 8 h
Result: Inhibited MAPK (ERK1/2, p38, JNK) phosphorylation and NF-κB/AP-1 nuclear translocation.
분자량

154.12

화학식

C7H6O4
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=CC1=CC(O)=C(O)C(O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도
In Vitro: 

DMSO : 116.67 mg/mL (757.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4885 mL 32.4423 mL 64.8845 mL
5 mM 1.2977 mL 6.4885 mL 12.9769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (13.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (13.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.92%

SDS (393 KB)

COA (250 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4885 mL 32.4423 mL 64.8845 mL 162.2113 mL
5 mM 1.2977 mL 6.4885 mL 12.9769 mL 32.4423 mL
10 mM 0.6488 mL 3.2442 mL 6.4885 mL 16.2211 mL
15 mM 0.4326 mL 2.1628 mL 4.3256 mL 10.8141 mL
20 mM 0.3244 mL 1.6221 mL 3.2442 mL 8.1106 mL
25 mM 0.2595 mL 1.2977 mL 2.5954 mL 6.4885 mL
30 mM 0.2163 mL 1.0814 mL 2.1628 mL 5.4070 mL
40 mM 0.1622 mL 0.8111 mL 1.6221 mL 4.0553 mL
50 mM 0.1298 mL 0.6488 mL 1.2977 mL 3.2442 mL
60 mM 0.1081 mL 0.5407 mL 1.0814 mL 2.7035 mL
80 mM 0.0811 mL 0.4055 mL 0.8111 mL 2.0276 mL
100 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.6221 mL
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Gallic aldehyde Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gallic aldehyde13677-79-7HSVMMPERKp38 MAPKJNKHerpes simplex virusMatrix metalloproteinasesExtracellular signal regulated kinasesc-Jun N-terminal kinaseantiviral activityInhibitorinhibitorinhibit

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상품명:
Gallic aldehyde
Cat. No.:
HY-W004486
수량:
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