2. Others Neuronal Signaling GPCR/G Protein Apoptosis Metabolic Enzyme/Protease PI3K/Akt/mTOR JAK/STAT Signaling Stem Cell/Wnt NF-κB
  3. Isotope-Labeled Compounds mGluR Ferroptosis Environmental Pollutants Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase mTOR STAT NF-κB
  4. L-Glutamine-15N2

L-Glutamine-15N2  (Synonyms: L-Glutamic acid 5-amide-15N2)

Cat. No.: HY-N0390S8 Purity: 99.95%
COA
SDS
Handling Instructions Technical Support

L-Glutamine-15N2 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

L-Glutamine-<sup>15</sup>N<sub>2</sub>

L-Glutamine-15N2 화학구조

CAS No. : 204451-48-9

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in Water 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of L-Glutamine-15N2:

L-Glutamine-15N2 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L-Glutamine-15N2

View All mGluR Isoform Specific Products:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Human Endogenous Metabolite Microbial Metabolite

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HIF-1α HIF

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mTOR mTORC1 mTORC2

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STAT3 STAT5 STAT6 STAT1

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

L-Glutamine-15N2 is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity[1][2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutamine-15N2 Related Antibodies
분자량

148.13

화학식

C5H1015N2O3
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[15NH2]C(CC[C@H]([15NH2])C(O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 50 mg/mL (337.54 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7508 mL 33.7541 mL 67.5083 mL
5 mM 1.3502 mL 6.7508 mL 13.5017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 99.95%

SDS (396 KB)

COA (245 KB) HNMR (236 KB) RP-HPLC (220 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7508 mL 33.7541 mL 67.5083 mL 168.7707 mL
5 mM 1.3502 mL 6.7508 mL 13.5017 mL 33.7541 mL
10 mM 0.6751 mL 3.3754 mL 6.7508 mL 16.8771 mL
15 mM 0.4501 mL 2.2503 mL 4.5006 mL 11.2514 mL
20 mM 0.3375 mL 1.6877 mL 3.3754 mL 8.4385 mL
25 mM 0.2700 mL 1.3502 mL 2.7003 mL 6.7508 mL
30 mM 0.2250 mL 1.1251 mL 2.2503 mL 5.6257 mL
40 mM 0.1688 mL 0.8439 mL 1.6877 mL 4.2193 mL
50 mM 0.1350 mL 0.6751 mL 1.3502 mL 3.3754 mL
60 mM 0.1125 mL 0.5626 mL 1.1251 mL 2.8128 mL
80 mM 0.0844 mL 0.4219 mL 0.8439 mL 2.1096 mL
100 mM 0.0675 mL 0.3375 mL 0.6751 mL 1.6877 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutamine-15N2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamine-15N2204451-48-9L-Glutamic acid 5-amide-15N2Isotope-Labeled CompoundsmGluRFerroptosisEnvironmental PollutantsEndogenous MetaboliteHIF/HIF Prolyl-HydroxylasemTORSTATNF-κBMetabotropic glutamate receptorsEnvironmental ContaminantsHypoxia-inducible factorsHIFsHIF-PHMammalian target of RapamycinNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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상품명:
L-Glutamine-15N2
Cat. No.:
HY-N0390S8
수량:
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