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Dexamethasone Sodium Phosphate

" in MedChemExpress (MCE) Product Catalog:

標的別:	Sodium Channel (1) 11β-HSD (1) 5 alpha Reductase (1) ADC Payload (4) Akt (1) Androgen Receptor (1) Antibiotic (8) Apoptosis (2) Autophagy (8) Bacterial (9) Biochemical Assay Reagents (3) CCR (2) Collagen (1) Complement System (8) COX (2) Cytochrome P450 (1) Drug Derivative (4) Drug Intermediate (17) Drug Metabolite (2) Endogenous Metabolite (2) Exosomes (8) FXR (1) Glucocorticoid Receptor (30) Interleukin Related (7) Isotope-Labeled Compounds (14) Mineralocorticoid Receptor (1) Mitophagy (8) Monoamine Oxidase (1) NF-κB (2) p38 MAPK (1) Phosphatase (1) Phospholipase (1) PI3K (1) PPAR (1) Progesterone Receptor (1) Reference Standards (10) RUNX (1) SARS-CoV (10) TGF-beta/Smad (1) TGF-β Receptor (4) Transmembrane Glycoprotein (1)
研究分野別:	Cancer (20) Cardiovascular Disease (2) Endocrinology (15) Infection (11) Inflammation/Immunology (34) Metabolic Disease (5) Neurological Disease (10)
クリックケミストリー:	Azide (1) Alkynes (1)
Oligonucleotides:	Aptamers (1) Cholesterol (1)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

ペプチド

阻害性抗体

天然物

同位体標識化合物

クリックケミストリー

オリゴヌクレオチド

Targets Recommended: Sodium Phosphate Cotransporter Sodium Chloride Cotransporter (NCC) Sodium Channel Glucose-6-Phosphate Isomerase (GPI) Na+/H+ Exchanger (NHE) Carbamoyl Phosphate Synthetase (CPS) PIKfyve SGLT PI4P5K Na+/K+ ATPase Apical Sodium-Dependent Bile Acid Transporter

製品番号	製品名	Target	研究分野	構造式

HY-14648

*Dexamethasone* Maximum Cited Publications 356 Publications Verification Hexadecadrol; Prednisolone F	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payload	Infection Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .

HY-B1829A

Dexamethasone phosphate disodium 10+ Cited Publications Dexamethasone 21-Phosphate diSodium	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-14648C

Dexamethasone (Water Soluble) Maximum Cited Publications 356 Publications Verification Dexamethasone cyclodextrin complex	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)

HY-14648A

Dexamethasone acetate 5+ Cited Publications Dexamethasone 21-acetate; Hexadecadrol acetate	Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery .

HY-128922

Dexamethasone palmitate DXP	Drug Intermediate	Inflammation/Immunology Endocrinology
Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation .

HY-P9965

Elotuzumab HuLuc 63; PDL 063; BMS 901608	Transmembrane Glycoprotein	Cancer
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma .

HY-129630

Tetrahydrocortisol	Drug Metabolite Glucocorticoid Receptor	Neurological Disease Cancer
Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-14648G

Dexamethasone 3 Publications Verification Hexadecadrol; Prednisolone F	Glucocorticoid Receptor ADC Payload	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor .

HY-118266

BTdCPU 3 Publications Verification	Phosphatase Apoptosis	Cancer
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma .

HY-14648R

Dexamethasone (Standard) Maximum Cited Publications 356 Publications Verification Hexadecadrol(Standard); Prednisolone F (Standard)	Reference Standards Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payload	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone (Standard) is the analytical standard of Dexamethasone. This product is intended for research and analytical applications. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-P10739

WYRGRL	Exosomes Collagen	Inflammation/Immunology
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC₅₀ of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis .

HY-B0727

Betamethasone valerate 1 Publications Verification Betamethasone 17-valerate	Glucocorticoid Receptor	Inflammation/Immunology
Betamethasone valerate (Betamethasone 17-valerate), the 17-valerate ester of Betamethasone, is a topical corticosteroid with anti-inflammatory activity. Betamethasone valerate is used in the treatment of recurrent aphthous stomatitis. Betamethasone valerate inhibits the binding of the radiolabeled glucocorticoid dexamethasone ( ³H dexamethasone) to human epidermis and mouse skin with IC₅₀s of 5 and 6 nM, respectively .

HY-101532

6A-Azido-6A-deoxy-β-cyclodextrin β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin	Biochemical Assay Reagents	Others
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-N0348

Dexamethasone 9,11-epoxide	Glucocorticoid Receptor Drug Intermediate	Inflammation/Immunology
Dexamethasone 9,11-epoxide is a type of glucocorticoid. Dexamethasone 9,11-epoxide can be used as a drug intermediate to prepare Dexamethasone (HY-14648) and Betamethasone (HY-13570). Dexamethasone 9,11-epoxide can be employed in the research of inflammation and immune diseases .

HY-14648S

Dexamethasone-d5 Hexadecadrol-d₅; Prednisolone F-d₅	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses .

HY-48917

C10 Bisphosphonate	Phospholipase Apoptosis	Inflammation/Immunology
C10 Bisphosphonate is an acid sphingomyelinase (aSMase) inhibitor with an IC₅₀ of 0.02 μM in rats. C10 Bisphosphonate inhibits Dexamethasone (HY-14648)-induced cell apoptosis (apoptosis) and alleviates platelet-activating factor (PAF)-induced pulmonary edema. C10 Bisphosphonate can be used for the research of pulmonary edema .

HY-14648AR

Dexamethasone acetate (Standard) Dexamethasone 21-acetate (Standard); Hexadecadrol acetate (Standard)	Reference Standards Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone acetate (Standard) (Dexamethasone 21-acetate (Standard)) is the analytical standard of Dexamethasone acetate (HY-14648A). This product is intended for research and analytical applications. Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery.

HY-P5832

BMP2-derived peptide	TGF-beta/Smad RUNX	Metabolic Disease
BMP2-derived peptide is an osteogenic inducer and BMP receptor ligand. BMP2-derived peptide binds to BMP receptors on the cell surface to form a complex, activates the downstream Smad signaling pathway, and regulates the expression of osteogenic transcription factors. BMP2-derived peptide effectively promotes the adhesion, proliferation, osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells, significantly up-regulates the mRNA levels of OCN, Runx2 and type I collagen, and increases alkaline phosphatase activity and calcium deposition. BMP2-derived peptide induces osteoblast differentiation and ectopic bone regeneration, and improves cranial bone defect repair. Meanwhile, BMP2-derived peptide enhances the cytocompatibility of mesoporous silica nanoparticles, synergistically increases osteogenic activity with Dexamethasone (HY-14648), serving as an important tool for bone defect repair research .

HY-103548

GSK9027	Glucocorticoid Receptor	Endocrinology
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone .

HY-131036

MAO-IN-M30 dihydrochloride	Monoamine Oxidase	Neurological Disease
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1829AR

Dexamethasone phosphate disodium (Standard) Dexamethasone 21-Phosphate diSodium (Standard)	Glucocorticoid Receptor Reference Standards Interleukin Related TGF-β Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium (Standard) is the analytical standard of Dexamethasone phosphate disodium (HY-B1829A). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).

HY-14648S3

Dexamethasone-4,6α,21,21-d4	Isotope-Labeled Compounds Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Metabolic Disease
Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-B1829

Dexamethasone phosphate 10+ Cited Publications Dexamethasone 21-Phosphate	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-128922S

Dexamethasone palmitate-d31	Isotope-Labeled Compounds Sodium Channel	Inflammation/Immunology
Dexamethasone palmitate-d31 is the deuterium labeled Dexamethasone palmitate(HY-128922).Dexamethasone palmitate (DXP) is a proagent of *Dexamethasone* (HY-14648). Dexamethasone palmitate can be used for the research of inflammation .

HY-14648S5

Dexamethasone-d3-1 Hexadecadrol-d₃-1; Prednisolone F-d₃-1	Isotope-Labeled Compounds Antibiotic Autophagy Glucocorticoid Receptor SARS-CoV ADC Payload Mitophagy Complement System Bacterial Exosomes	Cancer
Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-119790

Palmitoyllactic acid	PPAR	Metabolic Disease
Palmitoyllactic acid is a long-chain fatty acid with lipogenic activity. Palmitoyllactic acid can induce a brown fat-like phenotype in 3T3-L1 cells. Palmitoyllactic acid enhances the expression of a variety of brown/beige cell-specific genes, such as Prdm16 and Pgc1a. Palmitoyllactic acid acts similarly to PPARγ agonists, significantly enhancing adipogenesis in the presence of dexamethasone. Palmitoyllactic acid can be used in obesity research .

HY-129630S

Tetrahydrocortisol-d5	Isotope-Labeled Compounds Drug Metabolite Glucocorticoid Receptor	Neurological Disease Cancer
Tetrahydrocortisol-d₅ is the deuterium labeled Tetrahydrocortisol. Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer .

HY-Z3487

1,2-Dihydro dexamethasone	Drug Intermediate	Others
1,2-Dihydro dexamethasone is a Dexamethasone (HY-14648) impurity.

HY-114432

Dexamethasone impurity 3	Drug Intermediate	Others
Dexamethasone impurity 3 is an impurity of Dexamethasone (HY-14648).

HY-137197

6β-Hydroxy dexamethasone	Glucocorticoid Receptor	Inflammation/Immunology
6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648) .

HY-14648S2

Dexamethasone-d4 Hexadecadrol-d₄; Prednisolone F-d₄	Isotope-Labeled Compounds Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-W019682

Fmoc-FF	Biochemical Assay Reagents	Cancer
Fmoc-FF is a building block. Fmoc-FF-prepared hydrogels and nanogels selectively deliver Dexamethasone (HY-14648) to leukemia cells .

HY-128922R

Dexamethasone palmitate (Standard) DXP (Standard)	Drug Intermediate Reference Standards	Inflammation/Immunology Endocrinology
Dexamethasone palmitate (Standard) is the analytical standard of Dexamethasone palmitate. This product is intended for research and analytical applications. Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation .

HY-W753281R

Dexamethasone metasulfobenzoate sodium (Standard)	Reference Standards SARS-CoV	Infection
Dexamethasone metasulfobenzoate (sodium) (Standard) is the analytical standard of Dexamethasone metasulfobenzoate (sodium). This product is intended for research and analytical applications. Dexamethasone metasulfobenzoate sodium is a SARS-CoV-2 exonuclease (ExoN) inhibitor that binds to the catalytic site of ExoN .

HY-W753281

Dexamethasone metasulfobenzoate sodium	SARS-CoV	Infection
Dexamethasone metasulfobenzoate sodium is a SARS-CoV-2 exonuclease (ExoN) inhibitor that binds to the catalytic site of ExoN .

HY-14648S1

Dexamethasone-d5-1 Hexadecadrol-d₅-1; Prednisolone F-d₅-1	Isotope-Labeled Compounds Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology Cancer
Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-W754031

11-Dehydrodexamethasone	11β-HSD	Others
11-Dehydrodexamethasone, Dexamethasone (HY-14648) derivative, is a substrate for 11β-hydroxysteroid dehydrogenase (11β-HSD) 1/2. 11-Dehydrodexamethasone undergoes conversion to Dexamethasone via reductive activity of 11β-HSD .

HY-167845

LD03-DEX LD003	Interleukin Related	Inflammation/Immunology
LD03-DEX is a precursor compound of dexamethasone (HY-14648) with immunosuppressive activity .

HY-119722

Butafosfan	Endogenous Metabolite	Others
Butafosfan is a phosphate containing compound, which is used as active ingredient of veterinary drug. Butafosfan can stimulate the appetite, immune system and digestive function, improves liver and muscle function of dogs. Butafosfan can mitigate the adverse effects of Dexamethasone (HY-14648) on liver and pancreatic function in dogs .

HY-B1734

16-Dehydropregnenolone acetate 16-DPA	FXR 5 alpha Reductase Cytochrome P450 Drug Intermediate	Cardiovascular Disease Cancer
16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .

HY-125627

CP-394531	Glucocorticoid Receptor Androgen Receptor	Neurological Disease Metabolic Disease
CP-394531 is an efficient and highly selective non-steroidal glucocorticoid receptor (GR) antagonist, with a K_i value of 0.1 nM. CP-394531 has a weak binding to androgen receptor (AR) (K_i = 130 nM), and has almost no effect on progesterone receptor (PR) and estrogen receptors (ERα, ERβ). CP-394531 completely blocks the half-maximal agonistic effect induced by Dexamethasone (HY-14648G), with a K_if of 4.1 nM. CP-394531 can be used to study various diseases such as diabetes, obesity, depression, neurodegenerative diseases, glaucoma and Cushing's disease .

HY-B1829R

Dexamethasone phosphate (Standard) Dexamethasone 21-Phosphate (Standard)	Glucocorticoid Receptor Reference Standards TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Standard) (Dexamethasone 21-phosphate (Standard)) is the analytical standard of Dexamethasone phosphate (HY-B1829). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-B1829S

Dexamethasone phosphate-d4 Dexamethasone 21-Phosphate-d₄	Isotope-Labeled Compounds	Others
Dexamethasone phosphate-d₄ is the deuterium labeled Dexamethasone phosphate .

HY-147220

Dexamethasone oxetanone Dex-Ox	Progesterone Receptor	Endocrinology
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms .

HY-W744577

Dexamethasone acetate-d5 Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone acetate-d₅ (Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery.

HY-N0348R

Dexamethasone 9,11-epoxide (Standard)	Reference Standards Drug Intermediate	Inflammation/Immunology
Dexamethasone 9,11-epoxide (Standard) is the analytical standard of Dexamethasone 9,11-epoxide (HY-N0348). This product is intended for research and analytical applications. Dexamethasone 9,11-epoxide is an intermediate. Dexamethasone 9,11-epoxide can be used in the preparation of Dexamethasone (HY-14648). Dexamethasone 9,11-epoxide can be used in the research of inflammatory and immune diseases .

HY-164794

Pyridyl disulfide-Dexamethasone	Glucocorticoid Receptor	Inflammation/Immunology
Pyridyl disulfide-Dexamethasone is a Dexamethasone (HY-14648) modified with pyridyl disulfide, which can be used for the synthesis of targeted peptide steroid conjugates .

HY-106368

Dexamethasone cipecilate NS-126	Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone cipecilate (NS-126) is a corticosteroid whose local efficacy and durability have been enhanced by the introduction of a lipophilic functional group. Dexamethasone cipecilate can be used as a nasal spray and is applicable in rhinitis research .

製品番号	製品名	Type

HY-14648G

Dexamethasone 3 Publications Verification Hexadecadrol; Prednisolone F	蛍光色素
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor .

製品番号	製品名	Type

HY-14648G

Dexamethasone 3 Publications Verification Hexadecadrol; Prednisolone F	生化学アッセイ試薬
Dexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor .

HY-W777241

Dexamethasone β-D-glucuronide sodium

生化学アッセイ試薬

Dexamethasone β-D-glucuronide (sodium) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

製品番号	製品名	Target	研究分野

HY-P10739

WYRGRL	Exosomes Collagen	Inflammation/Immunology
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC₅₀ of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis .

HY-P5832

BMP2-derived peptide	TGF-beta/Smad RUNX	Metabolic Disease
BMP2-derived peptide is an osteogenic inducer and BMP receptor ligand. BMP2-derived peptide binds to BMP receptors on the cell surface to form a complex, activates the downstream Smad signaling pathway, and regulates the expression of osteogenic transcription factors. BMP2-derived peptide effectively promotes the adhesion, proliferation, osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells, significantly up-regulates the mRNA levels of OCN, Runx2 and type I collagen, and increases alkaline phosphatase activity and calcium deposition. BMP2-derived peptide induces osteoblast differentiation and ectopic bone regeneration, and improves cranial bone defect repair. Meanwhile, BMP2-derived peptide enhances the cytocompatibility of mesoporous silica nanoparticles, synergistically increases osteogenic activity with Dexamethasone (HY-14648), serving as an important tool for bone defect repair research .

HY-P11350

A666 peptide	ペプチド	Cancer
A666 peptide is a highly selective prestin ligand. A666 peptide enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

HY-W019682

Fmoc-FF	Biochemical Assay Reagents	Cancer
Fmoc-FF is a building block. Fmoc-FF-prepared hydrogels and nanogels selectively deliver Dexamethasone (HY-14648) to leukemia cells .

HY-P11350A

A666 peptide TFA	ペプチド	Cancer
A666 peptide TFA is a highly selective prestin ligand. A666 peptide TFA enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide TFA is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

製品番号	製品名	Target	研究分野	Image

HY-P9965

Elotuzumab HuLuc 63; PDL 063; BMS 901608	Transmembrane Glycoprotein	Cancer
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma .

HY-P992000

F8-IL-4	Interleukin Related	Inflammation/Immunology
F8-IL-4 is an immune cytokine targeting IL-4. F8-IL-4 specifically delivers IL-4 to inflammatory sites via binding to targets expressed on neovascular vessels. F8-IL-4 alleviates collagen-induced arthritis in mice by regulating T cell subsets and macrophage polarization. When combined with Dexamethasone (HY-14648), F8-IL-4 produces a synergistic and long-lasting therapeutic effect, and prevents arthritis recurrence after drug withdrawal by maintaining anti-inflammatory cell phenotypes and cytokine profiles. F8-IL-4 can be used in the research of collagen-induced arthritis .

製品番号	製品名	Category	Target	構造式

HY-129630

Tetrahydrocortisol	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Drug Metabolite Glucocorticoid Receptor
Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer .

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology Source Classification	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-119790

Palmitoyllactic acid	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	PPAR
Palmitoyllactic acid is a long-chain fatty acid with lipogenic activity. Palmitoyllactic acid can induce a brown fat-like phenotype in 3T3-L1 cells. Palmitoyllactic acid enhances the expression of a variety of brown/beige cell-specific genes, such as Prdm16 and Pgc1a. Palmitoyllactic acid acts similarly to PPARγ agonists, significantly enhancing adipogenesis in the presence of dexamethasone. Palmitoyllactic acid can be used in obesity research .

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	Structural Classification Flavonoids Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	COX Reference Standards CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-N14422

Collismycin B	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	Bacterial Glucocorticoid Receptor
Collismycin B is a potent dexamethasone-glucocorticoid receptor inhibitor with an IC₅₀ value of 10 µM. Collismycin B shows antimicrobial activity. Collismycin B shows cytotoxicity .

HY-N12489

Ishophloroglucin A	Structural Classification Marine algae Marine natural products Phenols Polyphenols Source Classification	PI3K Akt
Ishophloroglucin A is an orally active phlorotannin compound found in Ishige okamurae. Ishophloroglucin A can alleviate Dexamethasone (HY-14648)-induced muscle atrophy through muscle protein metabolism. Ishophloroglucin A can improve impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin ligase muscle RING finger and atrogin-1). Ishophloroglucin A can be used for research of muscle atrophy-related diseases .

製品番号	製品名	構造式

HY-14648S

Dexamethasone-d5

Dexamethasone-d₅ is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses .

HY-14648S3

Dexamethasone-4,6α,21,21-d4

Dexamethasone-4,6α,21,21-d₄ is the deuterium labeled Dexamethasone-4,6α,21,21. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-128922S

Dexamethasone palmitate-d31
Dexamethasone palmitate-d31 is the deuterium labeled Dexamethasone palmitate(HY-128922).Dexamethasone palmitate (DXP) is a proagent of *Dexamethasone* (HY-14648). Dexamethasone palmitate can be used for the research of inflammation .

HY-14648S5

Dexamethasone-d3-1

Dexamethasone-d₃-1 (Hexadecadrol-d₃-1; Prednisolone F-d₃-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-129630S

Tetrahydrocortisol-d5

Tetrahydrocortisol-d₅ is the deuterium labeled Tetrahydrocortisol. Tetrahydrocortisol is a metabolite of Hydrocortisone (HY-N0583) that fails to activate glucocorticoid receptor. Tetrahydrocortisol inhibits Dexamethasone (HY-14648)-induced formation of cross-linked actin networks. Tetrahydrocortisol acts as a synergist to enhance the activity of anticancer agents. Tetrahydrocortisol can be used in the research of primary open-angle glaucoma, ocular hypertension, lung cancer and breast cancer .

HY-14648S2

Dexamethasone-d4

Dexamethasone-d₄ is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-14648S1

Dexamethasone-d5-1

Dexamethasone-d₅-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

HY-B1829S

Dexamethasone phosphate-d4
Dexamethasone phosphate-d₄ is the deuterium labeled Dexamethasone phosphate .

HY-W744577

Dexamethasone acetate-d5

Dexamethasone acetate-d₅ (Dexamethasone 21-acetate-d₅; Hexadecadrol acetate-d₅) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery.

HY-W741425

*21-O-Acetyl dexamethasone* 9,11-epoxide-d5**
21-O-Acetyl dexamethasone 9,11-epoxide-d₅ is the deuterium labeled 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate (Dexamethasone Acetate Impurity) (HY-Z8003).

HY-167845S

Exemestane-19-d3
Exemestane-19-d₃ is the deuterium labeled LD03-DEX (HY-167845). LD03-DEX is a precursor compound of dexamethasone (HY-14648) with immunosuppressive activity .

HY-W740983S

Dexamethasone dipropionate-d5
Dexamethasone dipropionate-d₅ is the deuterium labeled Dexamethasone dipropionate. Dexamethasone dipropionate is a Dexamethasone (HY-14648) ester. Dexamethasone dipropionate can be used in the research of osteoarthritis .

HY-W743695

Dexamethasone acid ethyl ester-d5
Dexamethasone acid ethyl ester-d₅ is the deuterium labeled Dexamethasone acid ethyl ester.

HY-W750265

Dexamethasone Phosphate-d5
Dexamethasone Phosphate-d5 is the deuterium labeled Dexamethasone Phosphate-d5 (HY-W750265) .

HY-Z1578S

Dexamethasone impurity 2-d4
Dexamethasone impurity 2-d₄ (Betamethasone phosphate-d₄) is the deuterium labeled Dexamethasone impurity 2. Dexamethasone impurity 2 is an impurity of Dexamethasone (HY-14648).

製品番号	製品名		Classification

HY-101532

6A-Azido-6A-deoxy-β-cyclodextrin β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin		Azide
6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

製品番号	製品名		Classification

HY-167845

LD03-DEX LD003		Cholesterol
LD03-DEX is a precursor compound of dexamethasone (HY-14648) with immunosuppressive activity .

HY-160044

Apt-M13 aptamer sodium		Aptamers
Apt-M13 aptamer sodium is a mutant 33 nt aptamer based on the original aptamer for dexamethasone (HY-14648). Apt-M13 aptamer sodium can be combined with other nanomaterials for rapid detection of dexamethasone (HY-14648) .

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