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  5. Elotuzumab

Elotuzumab  (Synonyms: HuLuc 63; PDL 063; BMS 901608)

Cat. No.: HY-P9965 Purity: 98.58%
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Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma.

For research use only. We do not sell to patients.

CAS No. : 915296-00-3

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Description

Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma[1][2].

In Vitro

Elotuzumab (0.1-10 μg/mL; 4-20 h) upregulates the expression of CD107a, CD69 and CD54 on NK cells, and promotes the secretion of IFN-γ and TNF-α in a co-culture system of human PBMC and OPM-2 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Elotuzumab Related Antibodies
In Vivo

Elotuzumab (10 mg/kg; intraperitoneal injection; 3 times; once every 3-4 days) exhibits antitumor activity in a mouse tumor model expressing hSLAMF7, and the effect is better when used in combination with anti-PD-1 antibody[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice treated A20-hSLAMF7 cells or EG7-hSLAMF7 cells[2]
Dosage: 10 mg/kg (Elotuzumab in the form of murine IgG2a subtype)
Administration: Intraperitoneal injection; 3 times; once every 3-4 days
Result: Inhibited tumor growth, increased tumor-infiltrating NK cells and CD8+ T cells, and the expression of activation markers on these cells.
Promoted tumor-infiltrating NK and CD81 T-cell activation, as well as increased intratumoral cytokine and chemokine release by combination with anti-PD-1 antibody.
Clinical Trial
Molecular Weight

145.44 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Elotuzumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 98.58%

SDS (251 KB)

COA (232 KB) SDS-PAGE (59 KB) SEC-HPLC (97 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elotuzumab915296-00-3HuLuc 63 PDL 063 BMS 901608HuLuc63HuLuc-63PDL063PDL 063PDL-063BMS901608BMS 901608BMS-901608Othersmonoclonal antibodySLAMF7antimyeloma activityRRMMInhibitorinhibitorinhibit

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