SLAMF7 - SLAM family member 7 Gene

Also Known as 19A; CS1; CD319; CRACC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57823

About SLAMF7

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,739,057-160,754,821 (from NCBI)

This gene has 11 transcripts (splice variants), 138 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 22.3), appendix (RPKM 19.3) and 13 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in adaptive immune response. Predicted to act upstream of or within regulation of natural killer cell activation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SLAMF7 Products (10)

mRNA	Protein	Name
NM_001282588.2	NP_001269517.1	SLAM family member 7 isoform b precursor
NM_001282589.2	NP_001269518.1	SLAM family member 7 isoform c precursor
NM_001282590.2	NP_001269519.1	SLAM family member 7 isoform d
NM_001282591.2	NP_001269520.1	SLAM family member 7 isoform e
NM_001282592.2	NP_001269521.1	SLAM family member 7 isoform f precursor
NM_001282593.2	NP_001269522.1	SLAM family member 7 isoform g
NM_001282594.2	NP_001269523.1	SLAM family member 7 isoform h
NM_001282595.1	NP_001269524.1	SLAM family member 7 isoform i
NM_001282596.2	NP_001269525.1	SLAM family member 7 isoform j
NM_021181.5	NP_067004.3	SLAM family member 7 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15153464	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAMF7 Protein Structure

V-set

Ig_3

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
SLAM family member 7	19A24 protein

SLAMF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLAMF7	Q9NQ25	SLAMF7	Homo sapiens	Q9NQ25	FACS	15153464
Intra	SLAMF7	Q9NQ25	MAK	Homo sapiens	P20794	Y2H Array	21988832
Intra	SLAMF7	Q9NQ25	CMTM6	Homo sapiens	Q9NX76	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	PTCD2	Homo sapiens	Q8WV60	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	SLAMF7	Homo sapiens	Q9NQ25	Protein Array	21982860
Intra	SLAMF7	Q9NQ25	NCR3	Homo sapiens	O14931	FACS	15153464
Intra	SLAMF7	Q9NQ25	SH2D1B	Homo sapiens	O14796	SPR	24642916
Intra	SLAMF7	Q9NQ25	TBC1D23	Homo sapiens	Q9NUY8	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	CLK3	Homo sapiens	P49761	Y2H Array	21988832
Intra	SLAMF7	Q9NQ25	HUS1	Homo sapiens	O60921	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	TNFSF9	Homo sapiens	P41273	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	YIF1A	Homo sapiens	O95070	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	FBXO2	Homo sapiens	Q9UK22	Anti Tag CoIP	33961781
Intra	SLAMF7	Q9NQ25	SH2D1A	Homo sapiens	O60880	SPR	24642916
Intra	SLAMF7	Q9NQ25	NAGPA	Homo sapiens	Q9UK23	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72416	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9NQ25-1 (S23-M226)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72460	CRACC/SLAMF7 Protein, Human (HEK293, His)	Q9NQ25-1 (S23-M226)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77202	CRACC/SLAMF7 Protein, Human (HEK293, hFc)	Q9NQ25-1 (S23-M226)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77203	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, Fc)	Q9NQ25-1 (S23-M226)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P77205	CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His)	Q9NQ25-1 (S23-M226)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78517	CRACC/SLAMF7 Protein, Human (HEK293, mFc)	Q9NQ25-1 (S23-M226)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78518	CRACC/SLAMF7 Protein, Human (HEK293, His-Avi)	Q9NQ25-1 (S23-M226)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78642	FITC-Labeled CRACC/SLAMF7 Protein, Human (HEK293, His)	Q9NQ25-1 (S23-M226)	≥ 90%, as determined by reducing SDS-PAGE.

SLAMF7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81432	SLAMF7/CS1 Antibody (YA1177)	IHC-P	Human
HY-P81432A	SLAMF7/CS1 Antibody (YA1177)(PBS only)	IHC-P	Human
HY-P81747	SLAMF7/CS1 Antibody (YA1492)	FC, ELISA	Human
HY-P84817	SLAMF7/CS1 Antibody (YA4514)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84817A	SLAMF7/CS1 Antibody (YA4514)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit

Related Diseases

Diseases	Alias
Plasmablastic Lymphoma	Pbl Immunoblastic Large-Cell Lymphoma
Smoldering Myeloma
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Intellectual Developmental Disorder, Autosomal Dominant 10	MRD10 Mental Retardation, Autosomal Dominant 10 Autosomal Dominant Non-Syndromic Intellectual Disability 10 Autosomal Dominant Intellectual Developmental Disorder 10 Autosomal Dominant Mental Retardation 10 Mental Retardation, Autosomal Dominant, Type 10
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Igg4-Related Disease	Multifocal Fibrosclerosis Igg4-Related Sclerosing Disease Igg4-Related Systemic Disease Immunoglobulin G4-Related Sclerosing Disease Hyper-Igg4 Disease Igg4-Associated Disease Igg4-Positive Multiorgan Lymphoproliferative Syndrome Igg4-Related Autoimmune Disease Igg4-Related Systemic Sclerosing Disease Igg4-Syndrome Multifocal Idiopathic Fibrosclerosis Systemic Igg4-Related Plasmacytic Syndrome Systemic Igg4-Related Sclerosing Syndrome Mediastinal Fibrosis, Familial Retroperitoneal Fibrosis, Familial Igg4-Rd
Non-Secretory Myeloma
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9965	Elotuzumab	Inhibitor	99.9%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99454	Azintuxizumab vedotin		98.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12981	SLAMF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-172614	RK-0080552		/	Unkown
HY-RS16919	Slamf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23362	Slamf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99453	Azintuxizumab		≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLAMF7	VGNC	VGNC:34655
Canis familiaris	SLAMF7	VGNC	VGNC:46208
Mus musculus	SLAMF7	MGD	MGI:1922595
Macaca mulatta	SLAMF7	VGNC	VGNC:77547
Rattus norvegicus	SLAMF7	RGD	RGD:1560190
Felis catus	SLAMF7	VGNC	VGNC:107940
Others	SLAMF7	NCBI