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  5. SLAMF7/CS1 Antibody (YA1492)

SLAMF7/CS1 Antibody (YA1492)

Cat. No.: HY-P81747
User Guide for Antibodies Technical Support

SLAMF7/CS1 Antibody (YA1492) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLAMF7/CS1.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

SLAMF7/CS1 Antibody (YA1492) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLAMF7/CS1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 38 kDa;
Observed band size: 43 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Recombinant human CS1 protein
Application &
Dilution Ratio
Application Dilution Ratio
FC
FC: Flow Cytometry
1:50-1:100
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528); Isoform 3 does not mediate any NK cell activation
Subcellular Localization：Membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:This gene is expressed in the spleen, lymph nodes, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lungs, and trachea. Expression was detected in NK cells, activated B cells, and NK cell lines, but not in promyelocytes, B cells, or T cell lines. This gene is expressed in monocytes. Isomer 3 is expressed at a much lower level than isomer 1.
Isoforms & Post-Translational Modification：Q9NQ25 has 7 isomers: Q9NQ25-1: 37421 Da (predicted); Q9NQ25-2: 25831 Da (predicted); Q9NQ25-3: 37026 Da (predicted); Q9NQ25-4: 17945 Da (predicted); Q9NQ25-5: 32581 Da (predicted); Q9NQ25-6: 22785 Da (predicted); Q9NQ25-7: 21316 Da (predicted).
Subunit：Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536).
Database

Entrez Gene: 57823 Human

SwissProt: Q9NQ25 Human

OMIM: 606625 Human

Research Field

Immunology
Synonyms
SLAM7 (19A; CD319; CRACC; CS1)
Documentation
User Guide for Antibodies (1077 KB)

SLAMF7/CS1 Antibody (YA1492) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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