HUS1 - HUS1 checkpoint clamp component Gene

Also Known as hHUS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3364

About HUS1

Cytogenetic location: 7p12.3 Genomic coordinates (GRCh38): 7:47,963,288-47,979,615 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 3.6), thyroid (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

HUS1 Products (2)

mRNA Protein Name
NM_001363683.2 NP_001350612.1 checkpoint protein HUS1 isoform 2
NM_004507.4 NP_004498.1 checkpoint protein HUS1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10359610 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
21659603 GOA
involved in cellular response to ionizing radiation IDA
IDA: Inferred from direct assay
21659603 GOA
Cellular Component GO Annotation Evidence References Source
part of checkpoint clamp complex IDA
IDA: Inferred from direct assay
31776186 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10846170 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HUS1 Protein Structure

Hus1

Hus1: Hus1-like protein (1 - 279)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

checkpoint protein HUS1

  • HUS1 checkpoint homolog

HUS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HUS1 O60921 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Prey Pooling
32296183
Intra
HUS1 O60921 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Array
32296183
Intra
HUS1 O60921 GRIP1 Homo sapiens Q9Y3R0-3
Validated Y2H
32296183
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Anti Bait CoIP
10359610
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Y2H Array
32296183
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Anti Tag CoIP
33961781
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Y2H
10359610
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Anti Tag CoIP
28514442
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
X-Ray Diffraction
19464297
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Y2H Prey Pooling
32296183
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Density Sedimentation
14624239
Intra
HUS1 O60921 RAD9A Homo sapiens Q99638
Validated Y2H
32296183
Intra
HUS1 O60921 DCUN1D5 Homo sapiens Q9BTE7
Validated Y2H
32296183
Intra
HUS1 O60921 C4orf46 Homo sapiens Q504U0
Y2H Array
32296183
Intra
HUS1 O60921 C4orf46 Homo sapiens Q504U0
Validated Y2H
32296183
Intra
HUS1 O60921 C4orf46 Homo sapiens Q504U0
Y2H Prey Pooling
32296183
Intra
HUS1 O60921 RAD1 Homo sapiens O60671
Anti Tag CoIP
35271311
Intra
HUS1 O60921 RAD1 Homo sapiens O60671
Density Sedimentation
14624239
Intra
HUS1 O60921 RAD1 Homo sapiens O60671
X-Ray Diffraction
19464297
Intra
HUS1 O60921 RAD1 Homo sapiens O60671
Anti Tag CoIP
33961781
Intra
HUS1 O60921 RAD1 Homo sapiens O60671
Anti Tag CoIP
10359610
Intra
HUS1 O60921 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group G

  • Fanconi Anemia Complementation Group G

  • FANCG
Noonan Syndrome 4

  • NS4

  • Noonan Syndrome, Type 4
Noonan Syndrome 3

  • NS3

  • Noonan Syndrome, Type 3
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11232 NAB815 Inhibitor / Unkown
HY-RS06492 HUS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HUS1 MGD MGI:1277962
Bos taurus HUS1 VGNC VGNC:30008
Canis familiaris HUS1 VGNC VGNC:41840
Macaca mulatta HUS1 VGNC VGNC:73546
Rattus norvegicus HUS1 RGD RGD:1591976
Others HUS1 NCBI