RAD9A - RAD9 checkpoint clamp component A Gene

Also Known as RAD9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5883

About RAD9A

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,391,986-67,398,412 (from NCBI)

This gene has 11 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 9.1), skin (RPKM 8.8) and 25 other tissues.

Summary

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RAD9A Products (2)

mRNA	Protein	Name
NM_001243224.1	NP_001230153.1	cell cycle checkpoint control protein RAD9A isoform 2
NM_004584.3	NP_004575.1	cell cycle checkpoint control protein RAD9A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	10713044	GOA
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	11971963	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15326225	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10846170	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10359610	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12628935	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	21659603	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	9872989	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21659603	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of checkpoint clamp complex	IDA IDA: Inferred from direct assay	31776186	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12628935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD9A Protein Structure

Rad9

0
100
200
300
391 a.a.

Protein Preferred Names	Protein Names
cell cycle checkpoint control protein RAD9A	DNA repair exonuclease rad9 homolog A

RAD9A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Anti Bait CoIP	10359610
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Prey Pooling	32296183
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H Array	32296183
Intra	RAD9A	Q99638	HUS1	Homo sapiens	O60921	Y2H	10359610
Intra	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	10359610
Intra	RAD9A	Q99638	RAD1	Homo sapiens	O60671	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Tag CoIP	35271311
Intra	RAD9A	Q99638	RAD17	Homo sapiens	O75943	Anti Bait CoIP	20424596

Cross: Cross-species interaction Intra: Intraspecies interaction

RAD9A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81342	Rad9 Antibody (YA1087)	WB, IP	Human, Mouse, Rat, Monkey
HY-P81342A	Rad9 Antibody (YA1087)(PBS only)	WB, IP	Human, Mouse, Rat, Monkey
HY-P85570	Rad9 Antibody (YA5262)	WB, IP	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11614	RAD9A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21718	Rad9a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28236	Rad9a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAD9A	RGD	RGD:2319938
Macaca mulatta	RAD9A	VGNC	VGNC:76648
Bos taurus	RAD9A	VGNC	VGNC:33689
Felis catus	RAD9A	VGNC	VGNC:69218
Mus musculus	RAD9A	MGD	MGI:1328356
Canis familiaris	RAD9A	VGNC	VGNC:45322
Others	RAD9A	NCBI