DCUN1D5 - defective in cullin neddylation 1 domain containing 5 Gene

Also Known as DCNL5; SCCRO5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84259

About DCUN1D5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:103,050,686-103,092,160 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 3.6), fat (RPKM 1.6) and 25 other tissues.

Summary

Enables cullin family protein binding activity. Involved in cellular response to DNA damage stimulus; positive regulation of protein neddylation; and regulation of cell growth. Located in nucleus and spindle. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D5 Products (4)

mRNA Protein Name
NM_001318739.2 NP_001305668.1 DCN1-like protein 5 isoform b
NM_001318740.2 NP_001305669.1 DCN1-like protein 5 isoform c
NM_001318741.2 NP_001305670.1 DCN1-like protein 5 isoform c
NM_032299.4 NP_115675.1 DCN1-like protein 5 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cullin family protein binding IMP
IMP: Inferred from mutant phenotype
23201271 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23201271 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
23098533 GOA
involved in positive regulation of protein neddylation IMP
IMP: Inferred from mutant phenotype
23201271 GOA
involved in regulation of cell growth IMP
IMP: Inferred from mutant phenotype
24192928 GOA
involved in regulation of protein neddylation IMP
IMP: Inferred from mutant phenotype
19617556 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18445686 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
23098533 GOA
located in spindle IDA
IDA: Inferred from direct assay
18445686 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCUN1D5 Protein Structure

Cullin_binding

Cullin_binding: Cullin binding (119 - 231)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

DCN1-like protein 5

  • DCN1, defective in cullin neddylation 1, domain containing 5

DCUN1D5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCUN1D5 Q9BTE7 HUS1 Homo sapiens O60921
Y2H Array
32296183
Intra
DCUN1D5 Q9BTE7 HUS1 Homo sapiens O60921
Y2H Prey Pooling
32296183
Intra
DCUN1D5 Q9BTE7 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
DCUN1D5 Q9BTE7 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
DCUN1D5 Q9BTE7 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
DCUN1D5 Q9BTE7 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
DCUN1D5 Q9BTE7 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
DCUN1D5 Q9BTE7 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
DCUN1D5 Q9BTE7 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03600 DCUN1D5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DCUN1D5 VGNC VGNC:102873
Mus musculus DCUN1D5 MGD MGI:1924113
Canis familiaris DCUN1D5 VGNC VGNC:53330
Rattus norvegicus DCUN1D5 RGD RGD:1307008
Bos taurus DCUN1D5 VGNC VGNC:27938
Macaca mulatta DCUN1D5 VGNC VGNC:71775
Others DCUN1D5 NCBI