2. Others
  3. Others
  4. Dexamethasone palmitate

Dexamethasone palmitate  (Synonyms: DXP)

Cat. No.: HY-128922 Purity: ≥98.0%
COA Handling Instructions

Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation.

For research use only. We do not sell to patients.

Dexamethasone palmitate Chemical Structure

Dexamethasone palmitate Chemical Structure

CAS No. : 14899-36-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 76 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 76 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 88 In-stock
50 mg USD 187 In-stock
100 mg USD 319 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dexamethasone palmitate (DXP) is a proagent of Dexamethasone (HY-14648). Dexamethasone palmitate can be used for the research of inflammation[1][2].

In Vitro

Dexamethasone palmitate (100 μg/mL; 48 h) affects cytokines concentration of RAW 264.7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 100 μg/mL
Incubation Time: 48 hours
Result: Showed vitro anti-inflammatory effects and decreased LPS-induced MCP-1 and TNF-α concentration in RAW 264.7 cells.
In Vivo

Dexamethasone palmitate (1280 μg; IVT injection once) shows different distribution in ocular tissue at different times[2].
Dexamethasone palmitate (280-1280 μg; IVT injection once) affects VEGF-induced vascular hyperpermeability[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbits[2]
Dosage: 1280 μg
Administration: IVT injection; 1280 μg once
Result: Mostly distributed in vitreous and still existed till 9 months. The least distributed in aqueous humor and almost disappeared till 6 months.
Animal Model: New Zealand White rabbits with VEGF injection[2]
Dosage: 280, 560 and 1280 μg
Administration: IVT injection; 280-1280 μg once
Result: After 9 months administration VEGF-induced vascular permeability was controlled at a concentration of 1280 μg, besides 280 and 560 μg also reduced VEGF-induced vascular hyperpermeability after administration for 4 months.
Clinical Trial
Molecular Weight

630.87

Appearance

Solid

Formula

C38H59FO6
CAS No.
SMILES

C[[email protected]@]12[[email protected]](C[[email protected]@H](C)[[email protected]]2(O)C(COC(CCCCCCCCCCCCCCC)=O)=O)([H])[[email protected]@]3([H])[[email protected]@](F)([[email protected]@]4(C(CC3)=CC(C=C4)=O)C)[[email protected]@H](O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (79.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5851 mL 7.9256 mL 15.8511 mL
5 mM 0.3170 mL 1.5851 mL 3.1702 mL
10 mM 0.1585 mL 0.7926 mL 1.5851 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (3.30 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.30 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (241 KB) HNMR (209 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Dexamethasone14899-36-6DXPOthersprodruginflammationlipophilicRAW 264.7cytokineVEGFInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Dexamethasone palmitate
Cat. No.:
HY-128922
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email address *

Phone number

 

Department *

Organization name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.