Dexamethasone oxetanone
Based on 2 publication(s) in Google Scholar
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms.
For research use only. We do not sell to patients.
- CAS No.: 4089-36-5
- Formula: C22H27FO4
- Molecular Weight:374.45
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Storage:
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Dexamethasone oxetanone
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Biological Activity
Dexamethasone oxetanone (1 μM) exhibits significant quantities of agonist activity with transfected PR in CV-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4089-36-5
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Molecular Weight 374.45
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Formula C22H27FO4
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SMILES
C[C@@]12[C@@]3(C(CO3)=O)[C@@H](C[C@@]1([H])[C@@]4([H])[C@]([C@H](C2)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)C
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Synonyms
Dex-Ox
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cells
Oleic Acid and Transferrin Synergistically Induce Serum-Free Adipogenic Differentiation of Porcine Preadipocytes via the SEPTIN4/PPARγ Axis. [Abstract]2026 Apr 13;15(8):684. PMID: 42041552 -
Sci Rep
Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease. [Abstract]2025 Jul 1;15(1):21475. PMID: 40596380
Purity & Documentation
References
[1]. D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22. [Content Brief]
[2]. G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 200 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dexamethasone oxetanone Related Classifications
HY-147220 Related Classifications
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