4089-36-5
Chemical Structure
Dexamethasone oxetanone
Synonym(s): Dex-Ox
- CAS No.: 4089-36-5
- Formula:C22H27FO4
- Molecular Weight:374.45
IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,2'-oxetane]-3,3'(6H)-dione
InChIKey: PLIOZIVVVLFDAA-CXSFZGCWSA-N
SMILES: C[C@@]12[C@@]3(C(CO3)=O)[C@@H](C[C@@]1([H])[C@@]4([H])[C@]([C@H](C2)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)C
Biological Activity: Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
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Dexamethasone oxetanone | Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms. | |||||||||||||||||||||
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- [1]. D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22. [Content Brief]
- [2]. G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 200 [Content Brief]
Keywords
